极高危急淋亚型早期前体T细胞白血病的研究进展  

Early T-cell Precursor Leukaemia:A Subtype of Very High-risk Acute Lymphoblastic Leukaemia

作　　者：王学文[1] 

机构地区：[1]南京军区南京总医院血液病科,南京210002

出　　处：《医学综述》2011年第15期2305-2307,共3页Medical Recapitulate

摘　　要：起源于早期前体T细胞(ETPs)的急性淋巴细胞白血病(ETP-ALL)造成大约20%罹患该病的儿童死亡,其生物学的异质性尚未认识。CD5低表达与CD1a和CD8表达阙如并存即符合ETP基因型,ETP-ALL致癌的转录因子与典型T-ALL病例表达无明显差异,不能以此来分开这两种白血病亚型。ETP-ALL患者对标准加强化疗反应差,预后不佳,缓解失败或血液学复发的累积发生率以ETP-ALL亚组显著为高。About 20% of children with acute T cell-acute lymphoblastic leukaemia（T-ALL）originating from early T-cell precursors（ETPs）（ETP-ALL）succumb to the disease,suggesting an unrecognized biological heterogeneity.Weak CD5 expression combined with lack of CD1a and CD8 expression could be diagnosed as ETP-ALL,but no clear distinction between ETP-ALL and typical T-ALL cases could be made and used to identify subtypes of T-ALL on the basis of the expression of certain oncogenic transcription factors.Patients of ETP-ALL showed a poor prognosis with use of standard intensive chemotherapy,and the cumulative incidence of remission failure or hematologic relapse was significantly higher.

关 键 词：早期T前体细胞白血病 急性淋巴细胞白血病 基因表达 免疫表型 单核苷酸多态性阵列分析 

分 类 号：R733.71[医药卫生—肿瘤]