卒中遗传学研究进展  

Advances in stroke genetics

作　　者：黄振华[1] 郑卉[1] 邓镇[1] 潘速跃[1] 

机构地区：[1]南方医科大学南方医院神经内科,广州510515

出　　处：《国际脑血管病杂志》2011年第7期481-487,共7页International Journal of Cerebrovascular Diseases

摘　　要：无论是在中国和全世界范围内，卒中都是一种重要的公共卫生问题。近年来，卒中遗传学研究取得了很大进展，特别是全基因组关联研究（genome-wide association study，GWAS）和表观遗传学的出现给该领域带来突破性进展。它们分别从基因水平和环境因素层面研究卒中的发病机制。虽然目前仍存在众多问题，但卒中遗传学前景光明。Stroke is an important public health problem both in China and worldwide. Stroke gentetics research has made great progess in recent years, especially the genome-wide association study （GWAS） and the emergence of epigenetics, has brought a breakthrough in this field. They studied the pathogenesis of stroke from the ~naetic level and the environmental factor levels. Although there are still many problems to be solved, the prospect of stroke genetics is bright.

关 键 词：卒中 全基因组关联研究 后成说 遗传 表观基因组 多态现象 单核苷酸 DNA甲基化 组蛋白类 

分 类 号：R743.3[医药卫生—神经病学与精神病学]