缺血预处理对大鼠局灶性脑梗死的影响  

Influence of Ischemic Preconditioning on Focal Cerebral Infarction in Rats

作　　者：刘勇[1,2] 朱遂强[1] 王云甫[2] 李永霞[2] 刘光健[2] 胡锦全[2] 

机构地区：[1]华中科技大学同济医学院附属同济医院神经内科,武汉430030 [2]湖北医药学院附属太和医院神经内科,湖北十堰442000

出　　处：《中国康复》2011年第4期247-249,共3页Chinese Journal of Rehabilitation

摘　　要：目的:探讨缺血预处理(IP)对局灶性脑梗死预后的影响。方法:SD大鼠38只,随机分为模型组和IP组各19只。模型组建立大鼠局灶性大脑中动脉闭塞(MCAO)再灌注模型;IP组在行MCAO再灌注手术前7d内先行2次15min的IP。2组均于MCAO再灌注术后3h及7d时行Zea longa神经功能评分,然后断头取脑行TTC染色检测梗死体积。结果:MCAO术后3h2组大鼠均有程度不同的神经功能缺失。7d时IP组Zea longa神经功能缺失程度评分明显低于模型组,梗死体积明显小于模型组(均P<0.01)。结论:IP对大鼠局灶性脑梗死具有保护作用。Objective：To explore the influence of ischemic preconditioning on focal cerebral infarction in rats.Methods：SD rats were randomly divided into model group and pretreatment group.Middle cerebral artery occlusion（MCAO）-reperfusion model in rats was established in the model group.The pretreatment group underwent 20-min ischemic preconditioning two times 7 days before the surgery of MCAO-reperfusion.Neurological grading was conducted twice within 1 week after the surgery of MCAO-reperfusion.One week after the surgery of MCAO-reperfusion the rats were decapitated and the infarct volume was examined by TTC staining.Results：The neurological deficit had a fast improvement（P0.01） and the infarct volume was significantly reduced（P0.01） in the pretreatment group.Conclusion：Ischemic preconditioning has a protective effect on focal cerebral infraction in rats.

关 键 词：缺血预处理 脑梗死 神经功能 梗死体积 

分 类 号：R743.3[医药卫生—神经病学与精神病学]