生长抑素八肽对门脉高压患者脾切除+断流术后腹腔引流量的影响  

Effect of Somatostatin Octapeptide on Postoperative Abdominal Drainage in Patients with Portal Hypertension after Splenectomy Combined with Devascularization

作　　者：黄海江 郑军 徐益萍 

机构地区：[1]浙江省诸暨市人民医院肝胆外科,浙江诸暨311800

出　　处：《中国现代医生》2011年第25期101-102,共2页China Modern Doctor

摘　　要：目的研究生长抑素八肽对门脉高压患者脾切除+断流术后腹腔引流量的影响。方法回顾性分析60例肝硬化、门脉高压并食道静脉曲张患者的临床资料,其中33例行脾切除+断流术后2h使用生长抑素八肽0.1mg/6h,连续3d,另27例未使用生长抑素,记录术后3d血红蛋白丢失量和5d腹腔引流量。结果全组患者手术后恢复顺利,无死亡发生,但使用生长抑素组腹腔引流量及血红蛋白丢失量明显少于对照组(P<0.05)。结论术后早期使用生长抑素能降低门脉压力,显著减少脾切除+断流术后手术创面的渗血及术后腹水的形成。Objective To study effect of somatostatin octapeptide on postoperative abdominal drainage in patients with portal hypertension after splenectomy combined with devascularization. Methods Retrospectively analyzed the clinical data of 60 patients with liver cirrhosis, portal hypertension and esophageal varices, including 33 cases received somatostatin octapeptide at 2 hours after splenectomy combined with devascularization, 0.1mg/6h for 3 days, and the other 27 cases did not receive somatostatin, and recorded the amounts of hemoglobin loss of 3 days and abdominal drainage of 5 days after surgery. Results All patients recovered well after surgery and no deaths occurred. However, abdominal drainge and hemoglobin loss of using somatostatin group were significantly less than the control group （P 〈 0.05）. Conclusion Early using somatostatin can reduce portal hypertension, decrease postoperative abdominal drainge after splenectomy combined with devascularization.

关 键 词：肝硬化 门脉高压 脾切除联合断流术 生长抑素八肽 腹腔引流量 

分 类 号：R575.2[医药卫生—消化系统]