p16^(INK4A)在宫颈非典型鳞状细胞中的诊断作用  

The Role of p16^(INK4A) in Diagnosis of Atypical Squamous of Undermined Significance

作　　者：武玲 宋静慧[2] 

机构地区：[1]内蒙古妇幼保健院妇产科,呼和浩特010020 [2]内蒙古医学院第一附属医院妇产科,呼和浩特010050

出　　处：《医学综述》2011年第16期2511-2513,共3页Medical Recapitulate

摘　　要：目的探讨p16INK4A免疫细胞化学检测在筛查宫颈非典型鳞状细胞(ASCUS)中的作用。方法对148例宫颈细胞学检查结果为ASCUS的患者进行p16INK4A免疫细胞化学检测,随访组织活检结果,以病理学结果作为金标准。结果 148例ASCUS中,p16INK4A在经病理学确诊的慢性宫颈炎、宫颈上皮内瘤样病变(CIN)的Ⅰ、Ⅱ、Ⅲ和浸润癌的阳性表达率分别为0.9%、77.3%、91.7%、100%、100%。p16INK4A的表达在宫颈炎与CINⅠ、CINⅡ、CINⅢ级之间,宫颈炎与宫颈鳞癌之间阳性率均有显著性差异(P<0.05)。结论 p16INK4A在宫颈CIN及以上病变中高表达,对ASCUS可有效地进行分流监测。Objective To study the expression and significance of in atypical squamous of undermined significance（ASCUS） by thinprep cytologic test.Methods p16INK4A immuncytochemical examination was performed reflexively on 148 liquid-based pap smears that had been interpreted as ASCUS,followed up by biopsy histology.Results In patients with histologically confirmed as cervical inflammation,cervical intraepithelial neoplasia（CINⅠ,Ⅱ,Ⅲ）and cervical carcinoma,the positive rates of p16INK4A were 0.9%,77.3%,91.7%,100%,100%.The difference in the positive rates of p16INK4A between cervical inflammation and cervical intraepithelial neoplasia（CINⅠ,Ⅱ,Ⅲ）,between cervical inflammation and cervical carcinoma had statistical significance.Conclusion Overexpression of tumor suppression gene p16INK4A occurred in cervical intraepithelial neoplasia and invasive cervical cancer,so its protein may be an useful biomarker in cytological screening of ASCUS.

关 键 词：P16INK4A 非典型鳞状细胞 免疫细胞化学检测 

分 类 号：R737.33[医药卫生—肿瘤]