改良FOLFOX方案治疗晚期大肠癌24例临床观察  

Clinical study of L-OHP and 5-Fu/CF in the treatment of 24 cases with advanced colorectal Cancer

作　　者：李利[1] 林忠[1] 吕维泽[1] 

机构地区：[1]中山大学附属第五医院肿瘤科,519000

出　　处：《中国实用医药》2011年第23期3-4,共2页China Practical Medicine

摘　　要：目的观察改良的FOLFOX方案治疗晚期大肠癌的临床疗效和毒副反应。方法对24例晚期大肠癌患者,用奥沙利铂(L-OHP)85 mg/m2静脉滴注3 h,亚叶酸钙(CF)400 mg静脉滴注2 h,5-氟尿嘧啶(5-Fu)500 mg在CF滴完后静冲,其后再予5-Fu 2800 mg/m2深静脉连续滴注48 h,每2周重复给药,治疗4周期后评价疗效。结果 24例中,CR 1例,PR 8例,SD 11例,PD 4例,总有效率(CR+PR)为37.5%。主要毒副作用是外周神经毒性、恶心呕吐、骨髓抑制。结论改良FOLFOX方案治疗晚期大肠癌疗效确切,毒副反应可耐受,值得推广使用。Objective To evaluate the efficacy and toxicity of our modified FOLFOX regimen in advanced colorectal cancer（ACRC）.Methods 24 patients with advanced colorectal cancer were treated with L-OHP plus 5-Fu/CF.L-OHP 85 mg/m2 iv infusion for 3 hours d1,CF 400 mg in infusion for 2 hours followed by 5-Fu 500 mg iv after the ending of CF,the last 5-Fu 2800 mg/m2 continuous intravenous infusion for 48 hours.Repeated the regimen every 2 weeks.The effect was evaluated after 4 regimens.Results Among the total 24 cases,1 were CR,PR in 8,SD in 11,PD in 4.The total rate of effectiveness（CR ＋ PR）was 37.5 %.The major side effects were neurotoxicity,nausea and vomiting and myelosuppression.Conclusion This regimen is effective and well-tolerated on advanced colorectal cancer.It is worth of clinical application.

关 键 词：晚期大肠癌 联合化学治疗 毒副作用 

分 类 号：R735.34[医药卫生—肿瘤]