非霍奇金淋巴瘤应用CHVP和CHOP治疗方案的临床实验观察  

Comparision of the Therapeutic Effects of CHVP and CHOP Regimens For Non.Hodgkin＇Lymphoma

作　　者：徐丽[1] 吐尔逊江·司拉木[1] 杜春辉[2] 田刚[3] 

机构地区：[1]新疆喀什地区第一人民医院血液科,新疆喀什844000 [2]新疆喀什地区第一人民医院检验科,新疆喀什844000 [3]天津公安医院检验科,天津300040

出　　处：《现代检验医学杂志》2011年第4期118-119,122,共3页Journal of Modern Laboratory Medicine

摘　　要：目的比较舍长春地辛（VDS）的CHVP方案和含长春新碱（VCR）的CHOP方案治疗非霍奇金淋巴瘤（NHL）的疗效和不良反应。方法两种方案治疗患者各30例。结果两组患者的有效率分剐为76．67％和70．00％（P=0．34，P〉0．05）。临床受益率分别为93．33％和90．00％（X^2=0．01，P〉O．05）。两组血小板减少、胃肠功能紊乱和肝功异常比较差异均无统计学意义（x^2=0．01，P〉O．05；妒=0．29，P〉0．05；x^2=0．00，P〉0．05）。外周神经毒性为主要不良反应。CHVP组和CHOP组外周神经毒性的发生率分别为16．67％：和46．67％（x^2=6．24，P〈0．05）。结论应用含长春地辛（VDS）的CHVP方案治疗NHL疗效好，神经毒性低，值得临床推广。Objective To compare efficacy and toxicity of CHVP（with VDS） and CHOP（with VCR） regimens for Non- Hodgkin lymphoma. Methods 60 NHL patients were devided into two groups including 30 cases CHVP and 30 cases CHOP. The rate of response and toxicity for 2 regimens were detected by the standard method. Results The rate of response for CHVP and CHOP were 76.67 % and 70. 00% （x^2 = 0. 34, P〉 0. 05）, the clinical benefit rates were 93.330% and 90. 00% ,respectively（X^2=0. 01 ,P〉0. 05）. Major toxicity was alopecia,disorder of stomache and intestine,hepatic ruction, neurotoxicity （x^2= 0. 01, P 〉 0. 05 ; X^2 = 0. 29, P 〉 0. 05 ; X^2 = 0. 00, P 〉 0. 05）. Incidence neurotoxieity was lower in the CHVP group than in the CHOP group（16.67% vs 46.67%,X^2=6- 24,P〈0. 05）. Conclusion CHVP（with VDS） regimes may more effective for Non-Hodgkin lymphoma with lower toxicity. It should be used generally in clinic.

关 键 词：非霍奇金淋巴瘤 长春地辛 长春新碱 毒性 

分 类 号：R733[医药卫生—肿瘤] R969.4[医药卫生—临床医学]