CD133和CD45在非小细胞肺癌组织中的表达及临床意义  

Expressions and Clinical Significance of CD133 and CD45 in Non-Small Cell Lung Cancer Tissues

作　　者：程继荣[1] 邹静[1] 祖木热提.穆沙江 

机构地区：[1]新疆医科大学第五附属医院肿瘤诊疗中心,新疆乌鲁木齐830011

出　　处：《肿瘤基础与临床》2011年第4期284-286,共3页journal of basic and clinical oncology

基　　金：新疆医科大学科研创新基金(编号:W2008-1)

摘　　要：目的探讨CD133和CD45在非小细胞肺癌(NSCLC)组织中的表达及临床意义。方法采用免疫组织化学SABC法检测65例NSCLC组织中CD133和CD45的表达,分析两者与肿瘤大小、组织学类型、TNM分期、组织分化程度及淋巴结转移之间的关系。结果 CD133和CD45在NSCLC组织中的阳性表达率分别为69.2%(45/65)和41.5%(27/65)。CD133的表达与肿瘤大小、组织学类型、TNM分期、组织分化程度无关(P>0.05);有淋巴结转移者的CD133阳性表达率为82.5%(33/40),高于无淋巴结转移者的48.0%(12/25),差异有统计学意义(χ2=7.053,P=0.008)。CD45的表达与肿瘤大小、组织学类型、TNM分期和有无淋巴结转移无关(P>0.05);高、中分化者的CD45阳性表达率为53.7%(22/41),高于低分化者的20.8%(5/24),差异有统计学意义(χ2=5.433,P=0.019)。结论 CD133+/CD45-可能是NSLLC肿瘤干细胞的部分表型特征。Objective To investigate the expressions and clinical significance of CD133 and CD105 in non-samll cell lung cancer（NSCLC）.Methods SABC immunohistochemical stainning was used to detect the expressions of CD133 and CD45 in the 65 patients with NSCLC.The relationship between the expressions of CD133,CD45 and the tumor size,histological type,TNM stage,histological differentiation as well as lymphoid metastasis were analyzed.Results The positive expression rates of CD133 and CD45 were 69.2%（45/65） and 41.5%（27/65） respectively.There were no significant differences between the expression of CD133 and the tumor size,histological type,TNM stage as well as histological differentiation（P〉0.05）;the positive expression rate of CD133 in the patients with lymphoid metastasis was higher than that with non-lymphoid metastasis,they were 82.5%（33/40） and 48.0%（12/25） respectively（χ2=7.053,P=0.008）.There were no significant differences between the expression of CD45 and the tumor size,histological type,TNM stage as well as lymphoid metastasis（P〉0.05）;the positive expression rate of CD133 in the patients with high-grade and middle-grade differentiation was higher than that with low-grade differentiation,they were 53.7%（22/41） and 20.8%（5/24） respectively（χ2=5.433,P=0.019）.Conclusion CD133＋/CD45-can be the tumor stem cell phenotype in NSCLC.

关 键 词：非小细胞肺癌 CD133 CD45 肿瘤干细胞 

分 类 号：R734.2[医药卫生—肿瘤]