胸上段食管癌动态IMRT与3DCRT计划的剂量学对比研究  

Dosimetric Comparison Between Intensity-Modulated Radiotherapy and Conformal Radiotherapy for Upper Esophageal Carcinoma

作　　者：袁一枫[1] 李军[1] 谭飞[1] 葛和平[1] 茅冬俊[1] 

机构地区：[1]苏北人民医院放疗科,江苏扬州225001

出　　处：《肿瘤基础与临床》2011年第4期329-331,共3页journal of basic and clinical oncology

摘　　要：目的比较胸上段食管癌不同放疗计划的剂量学差异。方法对86例上段食管癌患者分别设计调强放疗(IMRT)和三维适形放疗(3DCRT)计划,利用剂量体积直方图来比较两种计划中靶区、危及器官的剂量学差异。结果与3DCRT相比,IMRT靶区覆盖率V95%更高,Dmean也更接近处方剂量,差异有统计学意义(P<0.05);IMRT的靶区适合度指数、靶区剂量不均匀性指数均更接近1;IMRT脊髓D01明显降低,双肺受量略高。结论 IMRT用于治疗胸上段食管癌优于3DCRT。Objective To compare the dosimetry of different radiation therapy plans for upper esophageal carcinoma.Methods Three-dimensional conformal radiation therapy（3DCRT） and intensity-modulated radiation therapy（IMRT） were designed respectively for 86 patients with upper esophageal carcinoma.Dose volume histogram was used to compare the target volume and organs at risks.Results Compared with 3DCRT,the target volume coverage of IMRT was higher,the Dmean was more close to the prescription dose（P〈0.05）;the conformity index and homogeneity index were more close to one,spinal cord′s D01 significantly reduced.Conclusion IMRT is better than 3DCRT for upper esophageal carcinoma.

关 键 词：上段食管癌 调强放疗 三维适形放疗 剂量体积直方图 

分 类 号：R730.55[医药卫生—肿瘤] R735.1[医药卫生—临床医学]