子宫动脉栓塞化疗与静脉全身化疗治疗宫颈癌的临床效果对比研究  

Comparison of effectiveness of uterine artery embolization and intravenous neoadjuvant chemotherapy in treating cervical carcinoma

作　　者：许晓峰[1] 

机构地区：[1]河南省商丘市第一人民医院妇产科,476100

出　　处：《中国实用医刊》2011年第18期24-26,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨两种途径新辅助化疗治疗Ih2-Ⅱb期宫颈癌的疗效。方法对我院2002年以来收治的83例Ib2～Ⅱb期行新辅助化疗的宫颈癌患者的临床病理资料进行回顾性分析，其中，经静脉全身化疗者（静脉组）42例，经子宫动脉栓塞化疗者（动脉组）41例。结果静脉组患者经新辅助化疗总反应率为86％（36／42）；动脉组总反应率为90％（37／41），两组比较差异无统计学意义（P〉0．05）。静脉组新辅助化疗后可手术率为81％（34／42），其中Ⅱb期可手术率为64％（7／11）；动脉组化疗后可手术率为85％（35／41），其中IIb期可手术率为68％（15／22），两组比较差异无统计学意义（P〉0．05）。两组患者新辅助化疗后在肿瘤反应率、宫旁缓解率、可手术率、手术时间、出血量和并发症发生率方面比较，差异无统计学意义（P〉0．05）。Ⅱb期患者经新辅助化疗后手术，术后病理检查发现宫旁仍有肿瘤浸润者动脉组显著低于静脉组，分别为13％、57％（P〈0．05）。静脉组和动脉组患者治疗后复发率分别为14％、16％，病死率分别为11％、8％，分别比较，差异均无统计学意义（P〉0．05）。结论两种途径的新辅助治疗后反应率、可手术率及手术难度相当；子宫动脉栓塞化疗对改善宫旁浸润效果更好。Objective To compare the effect of the two neoadjuvant chemotherapy in treating cervical cancer with I b2 - 11 b grade. Methods The clinical and pathological datas of 83 cervical cancer patients treated by neoadjuvant chemotherapy in our hospital since 2002 were retrospectively analyzed. Among them, 42 cases were treated by intravenous chemotherapy （the intravenous group） and 41 cases were treated by uterine artery embolization chemotherapy （the arterial group）. Results The overall response rate of the intravenous group after neoadjuvant chemotherapy was 86% （36/42） ; The overall response rate of the arterial group after neoadjuvant chemotherapy was 90% （37/41）, there was no significant difference between the two groups （P 〉 0. 05）. The operable rate of the intravenous group after neoadjuvant chemotherapy was 81% （34/42）, which including 64% （7/11）of II b phase; The operable rate of the arterial group after chemotherapy was 85% （35/41）, which including 68% （15/22）of Ⅱb phase, the difference of the two groups was not statistically significant （P 〉 0. 05 ）. The difference of two groups after neoadjuvant chemotherapy was not significant （P 〉 0. 05） in tumor response rate, uterine response rate, operative rate, operation time, blood loss and complication rates, lIb phase of the patients after neoadjuvant chemotherapy, pathological examination revealed that uterine artery group were still tumor invasion was significantly lower than the intravenous group, was 13%, 57%, respectively （P 〈0. 05）. The recurrence rate of intravenous group and the artery group after treatment were 14%, 16%, respectively,mortality was 11%, 8%, the difference was not statistically significant （P 〉 0.05）. Conclusions The response rate after neoadjurant therapy, surgery rate and the difficulty of operation of the two methods can be similar; The uterine artery embolization is better to improve the parametrial invasion.

关 键 词：宫颈癌 子宫动脉栓塞 静脉化疗 

分 类 号：R737.33[医药卫生—肿瘤]