脑梗死与慢性脑供血不足危险因素差异性研究  

Differences of risk factors lead to two different outcomes of cerebral infarction and chronic cerebral circulation insufficiency

作　　者：许康[1] 阮清源[1] 郭建敏[1] 陈小奇[1] 孙国兵[1] 李平[1] 

机构地区：[1]湖北省新华医院神经内科,湖北武汉430015

出　　处：《中国现代医学杂志》2011年第23期2922-2925,共4页China Journal of Modern Medicine

摘　　要：目的研究脑梗死与慢性脑供血不足(CCCI)危险因素的差异性。方法 176例住院患者,其中脑梗死患者101例,慢性脑供血不足者75例。测定两组患者的血浆同型半胱氨酸(Hcy)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)和高密度脂蛋白(HDL-C)水平,明确患者原发性高血压、Ⅱ型糖尿病诊断。采用非条件多因素二元Logistic回归统计方法,分析上述各危险因素中能够预测脑梗死或慢性脑供血不足两种不同转归的因素。结果在脑梗死或慢性脑供血不足患者中,上述各危险因素中仅高同型半胱氨酸血症一项差异有统计学意义(OR=5.426,P<0.001),其他危险因素之间差异无统计学意义。结论高同型半胱氨酸血症是脑梗死或慢性脑供血不足两种不同转归的预测因素,血同型半胱氨酸水平升高者并发脑梗死的几率高于慢性脑供血不足;而高血压病、Ⅱ型糖尿病及血脂异常三者并发脑梗死或慢性脑供血不足的几率没有差异。【Objective】 To study the differences in risk factors between the patients of cerebral infarction（CI） and chronic cerebral circulation insufficiency（CCCI）.【Methods】 176 inpatients of neurology in our hospital were included in the study,of which 101 cases with cerebral infarction and 75 cases with CCCI.Determination was performed on the levels of plasma concentrations of homocysteine（HCY）,cholesterol（TC）,triglyceride（TG）,low density lipoprotein（LDL-CH） and high density lipoprotein（HDL-CH） of two groups of patients.It was essential to make clear whether or not the patients have the medical history of hypertention,type Ⅱdiabetes,dyslipidemia.Binary Logistic regression analysis was used to find the predictors of two different outcomes,CI or CCCI,in the risk factors mentioned above.【Results】 Only hyperhomocysteinemia was found to be significantly different（OR=5.426,P〈0.001） between the patients with CI and with CCCI.【Conclusions】 Hyperhomocysteinemia is a predictor of two different outcome,CI or CCCI.There was a higher risk of suffering CI than CCCI for the cases with their blood homocysteine levels higher than normal,and not for the cases with hypertension,type Ⅱ diabetes mellitus or dyslipidemia.

关 键 词：同型半胱氨酸 脑梗死 慢性脑供血不足 

分 类 号：R743.33[医药卫生—神经病学与精神病学]