miR-155在重度子痫前期患者胎盘中的表达分析  

作　　者：苏莉[1] 

机构地区：[1]江苏省扬中市人民医院妇产科,212200

出　　处：《浙江临床医学》2011年第9期972-974,共3页Zhejiang Clinical Medical Journal

摘　　要：目的分析microRNA-155（miR-155）在重度子痫前期（PE）患者胎盘中表达情况。方法随机选择在我院产科行剖宫产手术的患者，孕周34～40周，重度子痫前期20例，正常妊娠组20例，利用半定量RT—PCR、实时定量qRT—PCR检验两组患者胎盘中miR-155的表达情况。结果miR-155在重度子痫前期组患者胎盘中较正常妊娠组高表达。结论本实验通过qRT—PCR验证了miR-155在PE和正常胎盘存在差异表达，提示miR-155高表达可能为PE的发病机制之一。Objective To investigate the expression profile of miR - 155 in the human placentas of patients with severe preeclampsia. Methods Placentas were obtained from patients with severe preeclampsia（ n = 20） and a control group with term delivery （ n = 20）. The varying levels of miR - 155 were assessed by real - time quantitative reverse transcription - polymerase chain reaction. Results The results show that miR - 155 amount in the human placentas of patients with severe preeclampsia was higher than that in the control group. Conclusion This study reports increased expression profile of miR - 155 is related to the development of severe preeclampsia. Furthermore, those findings reveal novel target for investigation of the pathophysiology of preeclampsia.

关 键 词：MIR-155 子痫前期 胎盘 

分 类 号：R730[医药卫生—肿瘤]