脱水穿心莲内酯/β-环糊精包合物的包合机制研究  

Studies on Inclusion Mechanism of 14-Deoxy-11,12-Didehydroandrographolide/β-Cyclodextrin

作　　者：李景华[1,2] 韩光[1] 焦文温[1] 张生杰[1] 华素[1] 

机构地区：[1]河南大学药物研究所,河南开封475004 [2]河南大学天然药物与免疫工程重点实验室,河南开封475004

出　　处：《河南大学学报（自然科学版）》2011年第5期473-477,共5页Journal of Henan University:Natural Science

基　　金：河南省科技厅基础与前沿项目(082300450390;河南省"中药药效物质与创新药物研究"创新型科技团队

摘　　要：通过对包合比例、主客体分子间相互作用力、包合部位和包合物稳定性的研究来阐明脱水穿心莲内酯和β-环糊精形成包合物的机制.应用差示热分析法确证包合物的形成,紫外分光光度法测定稳定常数并计算其热力学常数,1H-NMR、IR法确证包合部位.结果显示:脱水穿心莲内酯与β-环糊精形成了1∶1的包合物,包合部位为脱水穿心莲内酯的五元内酯环部分及十氢萘环部分,在形成包合物过程中范德华力起主要推动作用,疏水力起辅助作用,形成的包合物比较稳定.Studies on inclusion mechanism of 14-deoxy-11, 12-didehydroandro-grapholide and β-cyclodextrin in the inclusion ratio, the molecular interaction between host and guest, inclusion part and stability of inclusion compound. The formation of inclusion compound was confirmed by DTA; the equilibrium constants of inclusion compound was determined by UV and the calculated thermodynamic constants through Ka of various temperature; inclusion parts were confirmed by the 1H-NMR and IR. The results indicated that inclusion host-guest ratio is 1 ： 1, van der Waals forces play a major role in the process, inclusion site is five yuan lactone ring and decalin ring, the inclusion compound is more stable under normal temperature.

关 键 词：脱水穿心莲内酯 Β-环糊精 包合物 包合机制 

分 类 号：R9[医药卫生—药学]