不同粒径三七粉体物理特性及体外溶出行为的比较  

Comparison of physical characteristics and active ingredient dissolution behavior between fine powder and ultrafine powders of Panax notoginseng

作　　者：陈绪龙[1,2] 赵国巍[1] 廖正根[1] 梁新丽[1] 王光发[1] 祝婧云[1] 郭立玮[3] 张南[1] 

机构地区：[1]江西中医学院现代中药制剂教育部重点实验室,南昌330004 [2]九江学院临床医学院,九江332000 [3]南京中医药大学植物药研究与新药开发中心,南京210029

出　　处：《中华中医药杂志》2011年第9期1971-1974,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家中医药管理局公益性行业科研专项(No.200807054);江西省对外科技合作项目(No.2008BB24800);江西省教育厅青年科学基金项目(No.GJJ10214);江西省卫生厅中医药科研计划(No.2010A101);国家高技术研究发展计划(863计划)(No.2009AA043202)~~

摘　　要：目的:比较三七细粉和超微粉体物理特性及有效成份体外溶出行为的差异,为三七超微粉体的粒径控制与应用提供试验依据。方法:通过测定三七细粉和超微粉体的粒径、吸湿性、粉体的形貌结构、流动性等物理特性和体外溶出行为,研究三七粉体的粒径对其物理特性和体外溶出行为的影响。结果:随三七粉体粒度的减小,其比表面积及孔隙率增加,吸湿性增加,流动性减弱;微粉Ⅰ有效成分的溶出速率和累积溶出量均高于其它粉体。结论:适度的微粉化能促进三七有效成分的充分利用,超微粉碎技术应用于三七具有可行性和必要性。Objective： To compare the differences about physical characteristics and active ingredients dissolution behavior between fine powder and ultrafine powders of Panax notoginseng to provide experimental evidence for the ultrafine powder application and the control of particle size. Methods： Particle size, hygroscopicity, powder morphology of the physical properties and dissolution behavior was used to evaluate the impact of particle size on physical characteristics and dissolution of powders of Panax notoginseng. Results： With the particle size of powdersdecreased, the surface area, prosity and moisture increased, liquidity decreased; The cumulative dissolution rate of the active ingredients of utrafine powder I was significantly higher than the other powders. Conclusion： An appropriate degree of comminution can promote the full use of active ingredients of Panax notoginseng. Superfine comminution technology was feasible and necessary.

关 键 词：三七 超微粉碎 物理特性 体外溶出 

分 类 号：TQ461[化学工程—制药化工]