PLGA牙周引导组织再生膜的仿生矿化研究  

Biomimetic Mineralization of PLGA Guided Tissue Regeneration Membrane

作　　者：张华林[1] 冯佳[1] 李咏梅[1] 

机构地区：[1]宁夏医科大学口腔医学院,宁夏银川750004

出　　处：《哈尔滨医药》2011年第4期241-242,共2页Harbin Medical Journal

基　　金：教育部科学技术研究重点项目(211196);宁夏医科大学特殊人才科研启动项目(XT201006)

摘　　要：目的制备一种具有生物活性的的牙周引导组织再生膜并对其性能进行表征。方法先用溶液浇铸法制备PL-GA膜,再将其浸入配制好的矿化液中进行仿生矿化;采用SEM、XRD、EDX等检测手段分析矿化膜的矿化情况。结果随着矿化时间的延长,PLGA膜上形成的晶粒由小到大、由少到多,密度由稀疏到致密。仿生矿化后,PLGA膜上的沉积物以钙、磷元素为主;Ca/P摩尔比随仿生矿化时间的延长而增高,且摩尔比值随矿化时间的延长逐渐接近轻基磷灰石的Ca/P理论值1.67。结论仿生矿化是一种制备新型的、有生物活性的复合材料的简单、有效的方法。通过仿生矿化法制得的PLGA矿化膜有可能作为牙周引导组织再生膜材料在组织工程领域发挥作用。Objective To prepare a bioactive periodontal guided tissue regeneration membrane and characterize its properties.Methods PLGA membrane was prepared by solution casting method.Subsequently,the membrane was immersed in a supersaturated calcification solution for biomimetic mineralization.Scanning electron microscopy,Energy dispersive X-ray analysis and X-ray diffraction were used for characterization.Results The crystals on PLGA membrane became more,larger and denser as the mineralization times increased.It was found that after mineralization,apatite crystals were deposited on the PLGA/MWNTs composite scaffolds.After mineralization,the deposits were calcium and phosphorus-based;Ca/ P ratio increased with the time of biomimetic mineralization increasing,and the ratio was gradually close to the theoretical Ca/ P value of HA,that was 1.67.Conclusion Biomimetic mineralization may be an easy and effective method for preparing novel and bioactive composite materials.The mineralized PLGA membrane may be potentially useful in tissue engineering applications,particularly as periodontal guided tissue regeneration membrane.

关 键 词：PLGA 引导组织再生膜 仿生矿化 

分 类 号：R783.1[医药卫生—口腔医学]