α-突触核蛋白与帕金森病  

α-synuclein and Parkinson Disease

作　　者：卢芳[1] 周世慧[1] 董杨[1] 范振群[1] 刘树民[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《哈尔滨医药》2011年第4期293-295,共3页Harbin Medical Journal

基　　金：国家自然科学基金面上项目(81073019);高等学校博士学科点专项科研基金(20102327110004)

摘　　要：α-突触核蛋白(α-synuclein,α-Syn)是一种中枢神经系统突触前表达的可溶性蛋白质,与帕金森病(Parkinson disease,PD)的发生发展密切相关。α-突触核蛋白在各种因素的影响下异常表达和聚集,这一过程产生的氧化应激等生化反应和寡聚体中间构象等均在帕金森的发病过程中起重要作用。本文综述了近年的研究进展以探讨α-突触核蛋白在帕金森发病中的可能机制。α-synuclein（α-syn）is a soluble protein presynaptically expressed in central nervous system,and has a close relation with Parkinson disease（PD）.α-Syn may abnormally express or aggregate when it is affected by various factors.In these biochemical processes,many factors such as oxidative stress and intermediate conformation of oligomers,play important roles in the pathogenesis of PD.This paper reviewed recent researches to investigate the possible mechanisms of α-syn in PD development.

关 键 词：Α-突触核蛋白 帕金森病 机制 

分 类 号：R741[医药卫生—神经病学与精神病学]