疣状胃炎外周血T淋巴细胞亚群变化及亮菌口服液干预作用  

Alterations of peripheral blood T lymphocytes subgroup in verrucous gastritis patients and interventions effects of Armillariella oral solution

作　　者：丁西平[1] 王业涛[1] 郭春丽[1] 虞文永[1] 

机构地区：[1]安徽医科大学附属省立医院安徽省立医院消化内科,合肥230001

出　　处：《中国临床保健杂志》2011年第4期350-352,共3页Chinese Journal of Clinical Healthcare

摘　　要：目的探讨疣状胃炎外周血T淋巴细胞亚群变化及亮菌口服液干预作用。方法采用流式细胞分析仪检测30例疣状胃炎和30例浅表性胃炎患者外周血CD3+、CD4+及CD8+,30例疣状胃炎患者经过亮菌口服液干预治疗再检测外周血CD3+、CD4+及CD8+。结果疣状胃炎患者外周血T细胞亚群CD3+、CD8+低于浅表性胃炎,经过亮菌口服液干预后两者CD3+差异消失;Hp阳性疣状胃炎较Hp阴性疣状胃炎T细胞亚群CD4+高,经过亮菌口服液干预后CD4+下降;疣状胃炎合并胆汁反流与不合并胆汁反流CD3+、CD4+及CD8+无差异。结论疣状胃炎存在外周血T淋巴细胞亚群异常,亮菌口服液可改善疣状胃炎T细胞免疫作用。Objective To discuss the alterations of peripheral blood T lymphocytes subgroup in verrucous gastritis patients and observe intervention effect with Armillariella oral solution in these patients.Methods Peripheral blood CD^3＋,CD^4＋,CD^8＋ lymphocytes of 30 verrucous gastritis and 30 superficial gastritis patients were analyzed by flow cytometry and that of 30 verrucous gastritis patients were reanalyzed after having been intervened with Armillariella Oral Solution.Results Both of CD^3＋ and CD^8＋ lymphocytes percentages in peripheral blood of verrucous Gastritis patients were lower than of superficial gastritis patients respectively,the CD^3＋ lymphocytes difference between verrucous gastritis and superficial gastritis patients disappeared after having been intervened with Armillariella Oral Solution.The number of CD^4＋ lymphocytes in peripheral blood of HP positive verrucous gastritis patients was significantly higher than that of HP negtive,but this difference disappeared after intervention with Armillariella oral solution.There were no obvious differences in the numbers of CD^3＋,CD^4＋,CD^8＋ lymphocytes respectively between verrucous gastritis patients with and without btile reflux.Conclusion Abnormalities of T lymphocytes subgroup might exist in peripheral blood of verrucous gastritis patients and Armillariella Oral Solution seemed to improve T lymphocytes immunity of these patients.

关 键 词：胃炎 T淋巴细胞亚群 伞菌属 

分 类 号：R573.3[医药卫生—消化系统]