老年脑梗死患者高同型半胱氨酸血症与动脉粥样硬化斑块的相关性分析  

The correlation ship between the hyperhomocysteimia and atheroma in the cerebral infarction patients

作　　者：王姗姗[1] 王振福[1] 孙虹[1] 刘赛男[1] 陈海波[1] 王婷[1] 管锦群[1] 

机构地区：[1]解放军总医院南楼神经内科,北京100853

出　　处：《中国临床保健杂志》2011年第4期368-369,I0001,共3页Chinese Journal of Clinical Healthcare

摘　　要：目的探讨高同型半胱氨酸(Hcy)血症与动脉粥样硬化的相关性。方法测定脑梗死组和健康对照组的血清Hcy,利用彩色多普勒超声检查各组颈动脉粥样硬化情况,对比老年脑梗死患者和正常人的血清Hcy水平。结果脑梗死组血清Hcy水平为(19.63±6.74)μmol/L,而健康对照组血清Hcy水平为(13.76±3.95)μmol/L,两组比较差异有统计学意义(P<0.05)。血清Hcy水平与IMT增厚有显著相关性(P=0.004)。结论高Hcy血症是动脉粥样硬化形成的重要原因,是脑梗死发病的独立危险因素。Objective To investigate the association between the Hcy and atheroma progression in aged patients with cerebral infarction.Methods 60 consecutive hospitalized cerebral infarction patients whose carotid intima-media thickness（IMT）more than 1.2mm and 42 healthy controls were chosen in our study.Serum Hcy level was determined,and carotid atheroma was detected by color doppler ultrasound.Results The serum Hcy of the patient was higher significantly than that of the normal controls.The serum Hcy level was significantly associated with atheroma（P=0.004）.Conclusion The high serum Hcy level is an independent risk factor for cerebral infarction.

关 键 词：脑梗死 半胱氨酸 动脉粥样硬化 危险因素 

分 类 号：R743.33[医药卫生—神经病学与精神病学]