定量组织速度成像评价兔甲亢性心肌病模型的建立  

Evaluation on the establishment of levothyroxine-induced cardiomyopathy rabbit models with quantitative tissue velocity imaging

作　　者：王亚娟[1] 礼广森[1] 孙艳红[1] 张洁[1] 王伟东[1] 毕文君[1] 

机构地区：[1]大连医科大学附属第二医院超声科,辽宁大连116027

出　　处：《中国介入影像与治疗学》2011年第5期435-438,共4页Chinese Journal of Interventional Imaging and Therapy

基　　金：辽宁省科技厅科技计划项目(2009225009-7)

摘　　要：目的探讨定量组织速度成像(QTVI)技术评价左旋甲状腺素诱导建立兔甲亢性心肌病模型的价值。方法 30只新西兰纯种白兔分为实验组(n=20)和对照组(n=10)。对实验组每日腹腔注射左旋甲状腺素[45μg/kg体质量]建立甲亢动物模型,对照组兔每日腹腔注射生理盐水至实验结束。开始实验当日及第1、2、4周对两组兔行常规超声心动图及QTVI参数测定。实验结束后,实验组依据超声参数分为向心性肥厚亚组(CH亚组)和离心性肥厚亚组(EH亚组)。结果实验组兔第1周左心室射血分数(LVEF)、左心室短轴缩短率(LVFS)、二尖瓣口舒张期峰值流速(E)及二尖瓣环运动的收缩期平均峰值速度(Vs)、收缩期加速度(a)与基础状态比较明显增加(P<0.01);第2周后左心室后壁厚度(PWTd)、室间隔厚度(IVSTd)及左心室质量指数(LVMI)与基础状态及对照组比较明显增加(P<0.05),二尖瓣环舒张期峰值速度(Ve)明显减低(P<0.01)。与对照组比较,CH亚组Ve减低(P<0.01),EH亚组LVEF、LVFS、二尖瓣环平均Vs、a、二尖瓣环平均Ve明显减低(P<0.01)。结论 QTVI参数可有效评价兔甲亢性心肌病模型。Objective To assess the value of quantitative tissue velocity imaging（QTVI） in monitoring the establishment of levothyroxine-induced cardiomyopathy models on rabbits.Methods Thirty New Zealand purebred rabbits were divided into experimental group（n=20） and control group（n=10）.Hyperthyroidism models were established by peritoneal injection of levothyroxine（L-Thy） in experimental group（45 μg/ ）.The same dose of saline was given to rabbits in control group for 4 weeks.QTVI and conventional echocardiographic parameters were obtained at the beginning day and 1,2,4 weeks in two groups.According to the changes of ultrasound parameters,the rabbits of experimental group were divided into two subgroups： Concentric hypertrophy（CH） subgroup and eccentric hypertrophy（EH） subgroup.Results At the first week,left ventricular ejection fraction（LVEF）,fractional shortening（LVFS）,mitral inflow peak velocity（E）,average mitral annularsystolic peak velocity（Vs） and acceleration（a） increased obviously than before injection in experimental group（P0.01）.At the second week,posterior wall thickness at end diastole（PWTd）,interventricular septal thickness at end diastole（IVSTd） and left ventricular mass index（LVMI） increased obviously than before injection in experimental group and control group（P0.05）,and the average mitral annular early diastolic velocity（Ve） was significantly lower（P0.01）.Compared with control group,the average Ve was significantly lower in CH subgroup（P0.01）,while LVEF,LVFS,average Vs,a and average Ve were significantly lower in EH subgroup（P0.01）.Conclusion QTVI is valuable in the assessment of establishing levothyroxine-induced cardiomyopathy models on rabbits.

关 键 词：定量组织速度成像 超声心动描记术 心肌病 甲亢性 兔 

分 类 号：R-332[医药卫生]