血管紧张素Ⅱ2型受体基因A1675G多态性与脑梗死的关系  

Relationship between angiotensin Ⅱ 2 receptor gene A1675G polymorphisms and cerebral infarction

作　　者：和姬苓[1] 孙洪英[1] 张利荣[1] 程景丽[1] 张佳[1] 宋瑞琦[1] 杨国安[2] 

机构地区：[1]包头医学院第一附属医院神经内科,014010 [2]包头医学院第一附属医院基因诊断中心,014010

出　　处：《临床神经病学杂志》2011年第4期248-250,共3页Journal of Clinical Neurology

基　　金：内蒙古自治区自然科学基金项目(20080404MS1103)

摘　　要：目的探讨血管紧张素Ⅱ2型受体(AT2R)基因A1675G多态性与脑梗死的关系。方法采用病例对照研究,结合套式等位基因特异性引物(NASP)-PCR技术检测180例脑梗死患者和130名健康人(正常对照组)的AT2R基因1675位点的基因型和等位基因。比较和分析脑梗死组与正常对照组间该基因型及等位基因的分布频率差异,并运用Logistic回归分析脑梗死的危险因素。结果脑梗死组AT2R基因1675位点G等位基因频率(29.2%)明显低于正常对照组(51.8%)(P<0.05);男性对照亚组的G等位基因频率(48.8%)低于女性对照亚组(57.6%),但差异无统计学意义。男性脑梗死亚组G等位基因频率(21.4%)明显低于女性脑梗死亚组(43.6%)和男性对照亚组(48.8%)(均P<0.05)。女性脑梗死亚组G等位基因频率显著低于女性对照亚组(P<0.05)。Logistic回归分析显示,G等位基因降低脑梗死的发生概率(OR=0.38,P<0.05)。结论 AT2R基因A1675G多态性对脑梗死的发病有保护作用,并且对男性脑梗死发病具有更好的保护作用。Objective To approach the relationship between the angiotensin Ⅱ2 receptor （AT2R） gene A1675G polymorphism and cerebral infarction （CI）. Methods In the case-control study, the AT2R gene A1675G mononucleotide polymorphism was tested with nested allele-specific primer （NASP）-PCR in 180 CI patients and 130 healthy controls （ normal control group）. The distribution of genotype and allele frequencies in CI group and normal control group was analyzed and compared between the two groups, and the genetic factor was analyzed by Logistic regression analysis. Results The AT2R gene 1675 site G allele frequency in CI group （29.2%） was significantly lower than that in the normal control group （51.8%） （P 〈 0. 05 ）. G allele frequency in male control subgroup （48.8%） was significantly lower than that in the female control subgroup （57.6%）, but there was no statistical difference. G allele frequency in male CI subgroup（21.4% ） was significantly lower than that in female CI subgroup （43.6%） and male control subgroup（48.8% ） （all P 〈 0.05 ）. G allele frequency in female CI subgroup was lower than the female control subgroup, the difference had statistically significance （ P 〈 0. 05 ）. The Logistic regression analysis showed that AT2R gene G allele could decrease the rate of the CI （ OR = 0. 38, P 〈 0. 05）. Conclusions AT2R gene A1675G polymorphism has protective effect on CI, even better for male.

关 键 词：脑梗死 血管紧张素Ⅱ2型受体 基因多态性 性别 

分 类 号：R743.33[医药卫生—神经病学与精神病学]