重离子束治疗恶性黑色素瘤临床研究及疗效观察  

Recrudescent malignant melanoma cured by ^(12)C^(6+) heavy ion beam radiotherapy

作　　者：魏世华[1] 刘倩[2] 张红 李莎[1] 岳养军[1] 田种泽[1] 赵瑞[1] 陈小华[1] 

机构地区：[1]兰州军区兰州总医院放射治疗科,甘肃兰州730050 [2]中国食品药品检定研究院 [3]中国近代物理研究所

出　　处：《西北国防医学杂志》2011年第4期247-249,共3页Medical Journal of National Defending Forces in Northwest China

基　　金：国家重点基础研究发展计划(973计划)课题资助项目(2010CB834202);国家自然科学基金资助项目(60962004);甘肃省国际合作项目(090WCGA896)

摘　　要：目的:探讨我国自主研发的重离子加速器照射恶性黑色素瘤(MM)的临床疗效。方法:4例MM(3例术后复发,1例初治)自愿接受重离子照射的患者,1例位于下眼睑及内眦,1例位于大腿,1例位于腹股沟,1例位于足跟部及腘窝。2006-11～2008-09应用80～100 mev/U,12C6+重离子束,4例分别给于总剂量72～120.3 GyE/6～13 F照射(RBE=3)。结果:4例照射7个部位,3例4个部位肿块完全消失,达CR,另1例3个部位均缩小75%,达PR,有效率100%,疗中及疗后,皮肤有轻丶中度早反应改变。3例3年以上者随访局部肿块消失,均无远处转移。结论:12C6+重离子具有治疗精度高、疗程短,疗效显著等特点,特别在MM等射线抗拒的难治性肿瘤中,可达到常规放射治疗难以实现的效果。Objective：To explore the clinical effect of heavy ion synchrotron developed independently on malignant melanoma（MM）.Methods： During Jan.2007 to Sep.2008,four patients（3 cases recurrence after operation,one case without any treatment） with MM received irradiation（dose 72-120.3 GyE/ 6-13F,RBE=3） by carbon ion 12C6＋（80-100 mev/U）.The lesions located in lower eyelid and canthus（1 case）,thigh（1 case）,groin（1 case）,posterior heel and popliteal fossa（1 case）,respectively.Results： Seven lumps received irradiation,4 lumps in 3 patients completely disappeared（reach CR）,while 3 lumps in 1 patient reduced by 75%（reach PR）.The effective rate was 100%.During and after the treatment,there were some slight and mild skin side reactions.Lumps in 3 patients disappeared more than 3 years without invasion and metastasis.Conclusion： Carbon ion therapy is useful with higher therapeutic precision and shorter course of treatment in refractory tumors including MM.It offers a peerless therapeutic effect compared to routine radiotherapy.

关 键 词：黑色素瘤 恶性 重离子 放射疗法 

分 类 号：R739.5[医药卫生—肿瘤]