Gli-1蛋白在非小细胞肺癌中的表达及临床意义  

Expression of Gli-1 protein in non-small cell lung cancer and its clinical significance

作　　者：邹友成[1] 吕建发[1] 刘军涛[1] 李学刚[1] 毛志福[2] 

机构地区：[1]汉川汉川市人民医院胸外科,湖北431600 [2]武汉大学人民医院胸外科,430060

出　　处：《临床肿瘤学杂志》2011年第8期698-700,共3页Chinese Clinical Oncology

摘　　要：目的探讨Gli-1蛋白在非小细胞肺癌(NSCLC)组织中的表达情况及临床意义。方法应用免疫组化SP法检测65例NSCLC组织及其癌旁组织中Gli-1蛋白的表达,并结合患者的临床资料进行分析。结果在NSCLC组织中Gli-1蛋白阳性表达率为76.92%(50/65),高于相应癌旁组织的20.00%(13/65),差异有统计学意义(P=0.000)。Gli-1蛋白阳性表达率与NSCLC患者的组织学分级、临床分期和年龄有显著的相关性(P<0.05)。结论 Gli-1可能在NSCLC的进展中起重要作用,其蛋白表达可以作为一项临床诊断的重要指标。Objective To investigate the expression of Gli-1 protein in non-small cell lung cancer（ NSCLC）, and discuss the relationship between the expression and tumor＇s clinical and pathological characteristics. Methods The expression of Gli-1 protein was detected by immunohistochemical staining（SP） in 65 cases with primary NSCLC and the matched normal lung tissues,and the clinical data were analyzed. Results The positive rate of Gli-1 was 76.92% in NSCLC compared to the paired normal lung tissues（20. 00% ） with statistical significance（P = 0. 000） ; positive rate of Gli-1 correlated with tumor grade, clinical stage and age（ P 〈 0. 05 ）. Conclusion Gli-1 may play a key role in the progression of NSCLC and its protein might serve as an important target for the therapeutic intervention in clinic.

关 键 词：Gli-1蛋白 非小细胞肺癌 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]