不同种植术式对种植体周围软组织影响  

2-year results of implant treatment in the periodontal compromised region with intrabony defect： a case report

作　　者：蒋剑辉[1] 黄文秀[1] 杜志斌[1] 吴东[1] 陈江[1] 

机构地区：[1]福建医科大学附属口腔医院

出　　处：《中国口腔种植学杂志》2011年第1期28-29,共2页Chinese Journal of Oral Implantology

摘　　要：目的:从炎症水平和微循环变化出发研究两种术式的软组织愈合。方法:拔除6只成年Beagle犬双侧下颌前磨牙,拔牙创愈合8周后,按不同观察时间点植8周、4周、2周组共计36颗标准种植体。观察种植体龈沟探诊深度(GCD)、龈沟探诊出血指数(SBI);种植体龈沟液量(GCF)、及其中天冬氨酸转氨酶(AST)和碱性磷酸酶(ALP)含量;牙龈退缩程度;血管内皮生长因子(VEGF)表达及微血管密度(MVD)。整个实验过程每周给予口腔卫生维护1次。结果:2周组GCF、AST、ALP翻瓣大于不翻瓣(p<0.05);4周组GCF翻瓣大于不翻瓣(p<0.05),AST、ALP无明显差异(p>0.05);8周组GCF、AST、ALP无明显差异(p>0.05)。翻瓣组和不翻瓣组各自组内差异有统计学意义(p<0.05)。2周组唇侧牙龈VEGF免疫组化染色OD值翻瓣大于不翻瓣(p<0.01);4周、8周组唇侧牙龈VEGF免疫组化染色OD值不翻瓣大于翻瓣(p<0.01、p<0.05)。翻瓣及不翻瓣2周组VEGF免疫组化染色OD值大于正常组,翻瓣8周组小于正常(p<0.05)。2周、4周组MVD无明显差异(p>0.05),8周组不翻瓣大于翻瓣(p<0.05),且翻瓣组小于正常牙龈组织(p<0.05)。4周组、8周组唇侧牙龈退缩程度翻瓣明显大于不翻瓣(p<0.05、p<0.01)。结论:不翻瓣术式术后炎症反应水平明显低于翻瓣术式;牙龈局部微循环不翻瓣术式优于翻瓣术式;牙龈外形上翻瓣术式的种植体唇侧牙龈退缩程度大于不翻瓣术式。The present study reports on one patient who underwent dental implant therapy in previously periodontally compromised region with huge intrabony defect.6 months after the intrabony debridement and bone grafting with collagenous bone graft（Bio-Oss Collagen ,Geistlich Pharma AG,Wolhusen,Switzerland）,the intrabony defect was completely filled with regenerated hard tissue.Then two implants （Camlog Screw Line,Camlog Biotechnologies） were successfully placed.30 months after the bone grafting and 24 months after the implants placement,both of the peri-implant hard and soft tissues were healthy and stable.This report suggests that the previously huge intrabony defect and yet successfully treated may not have negative effects on the success of dental implant.

关 键 词：种植体 周围软组织 术式 免疫组化染色 血管内皮生长因子 BEAGLE犬 天冬氨酸转氨酶 牙龈退缩 

分 类 号：R783[医药卫生—口腔医学]