吸烟因素对大鼠种植体骨整合的影响  

作　　者：李黛 侯玉东[2] 季晓妮 

机构地区：[1]烟台市口腔医院修复科,264001 [2]滨州医学院口腔学院,256603

出　　处：《中国口腔种植学杂志》2011年第1期55-55,共1页Chinese Journal of Oral Implantology

摘　　要：目的：探讨吸烟因素对大鼠胫骨内种植体骨整合的影响。方法：全麻下在32只Wistar大鼠右侧胫骨内植入纯钛螺纹状种植体,根据熏烟时间随机将其分为对照组、中止熏烟组和持续熏烟组,3个月后行X线片和骨密度测定。而后处死动物取胫骨标本,扫描电镜下观察各组种植体骨整合情况。实验数据以均数正负标准差表示,以SPSS？13.0软件对数据行单因素方差分析。结果：胫骨和种植体-骨界面平均密度值低,持续熏烟组与对照组间存在差异（F=6.808,P〈0.05）;X线片和扫描电镜下,持续熏烟组种植体-骨界面骨形成量少,矿化程度低,骨整合效果差。结论：吸烟因素对大鼠胫骨种植体骨整合有负面作用。Objective： The aim of this study was to evaluate the influence of cigarette smoke inhalation （CSI） on the osteointegration of pure titanium implants in the tibiae bone of rats.Methods： After anesthesia,a pure titanium implant was placed in the right tibia of each rat.According to the time of smoking,32 rats were randomly assigned to one of the following groups： Namely,the control group,smoking cessation group and continuous smoking group.3 months later,double energy X-ray absorptiometry and radiological observations were obtained.At the end of the experimental period,the animal were sacrificed,the tibiae were removed for the scanning electron microscope （SEM）.Statistical analysis was performed using SPSS 13.0 software package for one-way ANOVA.Results： The results showed that continuous cigarette smoking promoted a significantly reduced bone density in the bone-implant area and tibiae（F=6.808,P〈0.05）.Poor osseointegration was obtained by X-ray and SEM.Conclusion： Within in the limits of the present study,it can be concluded that cigarette smoke inhalation has a negative effect on osseointegration of implant inserted in rats.

关 键 词：Wistar大鼠 骨内种植体 骨整合 吸烟 种植体-骨界面 单因素方差分析 扫描电镜 骨内植入 

分 类 号：R783[医药卫生—口腔医学]