不同剂量地塞米松对小鼠前胃鳞状上皮增生癌变的影响  

A STUDY OF EFFECTS ON MOUSES FORESTOMACH EPI-THELIAL PROLIFERATION CANCERATION WITH DIFFERENT DOSAGES OF DEXAMETHASONE

作　　者：杜华贞[1] 付怀平[1] 千高峰[1] 和瑞芝[1] 常东明[2] 任金平[1] 

机构地区：[1]新乡医学院病理学教研室 [2]新乡医学院药理学教研室

出　　处：《新乡医学院学报》1990年第4期275-278,共4页Journal of Xinxiang Medical University

摘　　要：本文通过不同剂量地塞米松对小鼠前胃鳞状上皮影响的实验研究,观察了大小两个剂量的作用效果。灌喂大剂量地塞米松(12mg/kg),经两次重复动物实验,70天和120天的抑制癌变率分别在77.78％和46.15％左右。同时也促使癌组织向成熟方向分化。灌喂小剂量地塞米松(1mg/kg),70天和120天时诱发癌变率分别为43.75％和36.06％左右。并讨论了地塞米松抑制小鼠前胃上皮增生,癌变的机理。In this paper the effects on the mouses forestomach epithelial with different dosages of dexamethasone was observed. In order to observe the various effects of small or large dosages of dexamethasone, the mice were fed through perfusion (12mg/kg) and the experiment was repeated twice. The inhibited carcinogenicity rate in 70 day and 120 days is 77.78％ and 46.15％ separately, and the tissue promotes the cancer structure to mature. With small dosage (1mg/kg), The carcinogenictity rate provoked in 70 and 120 days is 43.76％ and 36.06％. The mechanisms of proliferation and the canceration in the mouses forestomach epithelial inhibited by dexametheasone are also discussed.

关 键 词：地塞米松 胃肿瘤 癌变 

分 类 号：R735.2[医药卫生—肿瘤]