四种辅助治疗方案联合手术对中晚期食管癌疗效的对比研究  

A Comparison of Surgery with Four Different Adjuvant Therapies in the Treatment for Advanced Esophageal Cancer

作　　者：左传田[1] 茅乃权[1] 刘德森[1] 黄鼎铭[1] 潘泓[1] 谢彤[1] 黄耀元[1] 潘琪[1] 杨立[1] 

机构地区：[1]广西医科大学附属肿瘤医院,广西南宁530021

出　　处：《肿瘤学杂志》2011年第7期518-520,共3页Journal of Chinese Oncology

基　　金：广西科学基金项目(桂科回0342024)

摘　　要：[目的]分析辅助治疗对中晚期食管癌的临床价值。[方法]230例中晚期食管癌（T2-4NXMO）患者,按照治疗方法分成4组,NRT组予术前放疗,NCRT组予术前放化疗,PRT组予术后放疗,PCRT组予术后放化疗,分析4组复发率、5年生存率。[结果]NRT、NCRT、PRT、PCRT组1年局部复发率分别为72.8%、30.7%、80.1%、35.6%,差异有显著性（χ2=4.159,P=0.000）;5年生存率分别为8.82%、33.33%、14.28%和19.18%,差异有显著性（χ2=13.812,P=0.003）。[结论]术前放化疗治疗中晚期食管癌可降低局部复发率,并提高远期生存率。[Purpose] To investigate the clinical efficacy of surgery with four adjuvant therapies in the treatment for advanced esophageal cancer（AEC）. [Methods] A total of 230 cases wtih AEC T2~4NXM0 were divided into 4 groups： radiotherapy followed by surgery（NRT-group）, chemoradiotherapy followed by surgery （NCRT-group）, radiotherapy after surgery（PRT-group） and chemoradiotherapy after surgery（PCRT-group）. Recurrence rate and 5-year survival in 4 groups were analyzed. [Results] The recurrence rate was 72.8%,30.7%,80.1% and 35.6% in NRT,NCRT,PRT and PCRT group respectively, with significant significance（χ2=4.159,P=0.000）, and the 5-year survival rate, 8.82%, 33.33%, 14.28% and 19.18% respectively（χ2=13.812, P=0.003）. [Conclusion] Neoadjuvant chemoradiotherapy can reduce recurrence rate and improve survival for AEC.

关 键 词：食管肿瘤 术前放疗 术前放化疗 生存率 

分 类 号：R735.1[医药卫生—肿瘤]