MIF基因-173位点G/C多态性与子宫内膜异位症遗传易感性的研究  

Study on G/C polymorphism of-173 locus in MIF gene and hereditary susceptibility of endometriosis

作　　者：王春平[1] 石丽萍[1] 于雅[1] 石瑾秋[1] 康春阳[1] 许学岚[1] 

机构地区：[1]广东省深圳市罗湖区人民医院妇产科,518001

出　　处：《中国妇幼保健》2011年第25期3925-3927,共3页Maternal and Child Health Care of China

基　　金：深圳市罗湖区科技局立项课题〔200902166〕

摘　　要：目的:探讨MIF基因-173位点G/C多态性与子宫内膜异位症的遗传易感性的相关性。方法:应用聚合酶链反应-限制性片断长度多态性技术(PCR-RFLP分析技术)检测广东籍汉族生育期妇女子宫内膜异位症患者49例(内异症组)和非子宫内膜异位症者49例(对照组)的MIF基因-173位点G/C单核苷酸多态性。结果:①内异症组MIF基因-173位点GG、GC、CC 3种基因型分布频率分别为53.06%、34.69%、12.25%;对照组MIF基因-173位点GG、GC、CC 3种基因型的分布频率分别为61.23%、32.65%、6.12%,两组间基因型的分布频率比较差异无统计学意义(P>0.05)。②MIF基因-173位点G、C等位基因型在内异症组中的分布频率分别为70.41%、29.59%,在对照组中分别为77.55%、22.45%,两组间等位基因型频率比较差异无统计学意义(P>0.05)。结论:MIF基因-173位点G/C多态性可能与广东汉族妇女人群子宫内膜异位症的遗传易感性无关。Objective： To explore the correlation between G/C polymorphism of - 173 locus in macrophage migration inhibitory factor （MIF） gene and hereditary susceptibility of endometriosis. Methods： PCR -PFLP technique was used to detect G/C single nucleotide polymorphisms of - 173 locus in MIF gene of 49 women of childbearing age with endometriosis （endometriosis group） and 49 women without endometriosis （control group） of Han nationality in Guangdong, Results： In endometriosis group, the distribution frequencies of GG genotype, GC genotype and CC genotype of - 173 locus in MIF gene were 53.06%, 34. 69% and 12. 25%, respectively; in control group, the distribution frequencies of GG genotype, GC genotype and CC genotype of - 173 locus in MIF gene were 61.23% , 32. 65% and 6. 12% , respectively, there was no significant difference between the two groups （ P 〉 0. 05 ） . The distribution frequencies of G allele and C allele of -173 locus in MIF gene were 70.41% and 29. 59% in endometriosis group, 77. 55% and 22. 45% in control group, respectively, there was no significant difference between the two groups （P 〉 0. 05） .Condusion： G/C polymorphism of -173 locus in MIF gene may be independent of hereditary susceptibility of endometriosis in Han women in Guangdong.

关 键 词：子宫内膜异位症 巨噬细胞移动抑制因子 基因多态性 疾病遗传易感性 

分 类 号：R711.71[医药卫生—妇产科学]