磷脂酰肌醇3-激酶在血管新生相关性疾病中的作用  

Effect of phosphatidylinositol 3-kinase in angiogenesis-related diseases

作　　者：权伟[1] 张丽莙[1] 

机构地区：[1]天津医科大学基础医学院病理生理学教研室,天津300070

出　　处：《中国病理生理杂志》2011年第8期1643-1646,共4页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.30971225);教育部科学技术研究重点资助项目(No.206008)

摘　　要：血管新生参与了人体多种生理与病理过程，前者如创伤愈合，后者包括肿瘤。Angiogenesis is involved in the pathological processes such as wound healing, atherosclerosis, rheumatoid arthritis and tumor, in which the pathogenesis and development are closely related to the new blood vessel formation. Phosphatidylinositol 3 - kinase （ PI3K）, one of the important intracellular signaling proteins, mediates many signal transductions in cell migration, proliferation and angiogenesis. The activity of PI3K and its signaling pathway play a unique role in atherogenesis, unstability of atherosclerotic plaque, tumor metastasis and recurrence, etc. This review summarizes the effect of PI3K in angiogenesis - related diseases.

关 键 词：血管生成 动脉粥样硬化 肿瘤 关节炎 类风湿 信号通路 磷脂酰肌醇3-激酶 

分 类 号：R363[医药卫生—病理学]