女性人类免疫缺陷病毒相关脂肪营养不良综合征患者体成分变化特点  

Change in Body Compositions in Female Patients with Human Immunodeficiency Virus-related Lipodystrophy Syndrome

作　　者：姚金朋[1] 余卫[1] 李太生[2] 罗玲[2] 林强[1] 田均平[1] 畅银娟[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院放射科,北京100730 [2]中国医学科学院北京协和医学院北京协和医院感染内科艾滋病诊疗中心,北京100730

出　　处：《中国医学科学院学报》2011年第4期421-426,共6页Acta Academiae Medicinae Sinicae

基　　金：国家十一五科技重大专项课题(2008ZX10001-006);卫生部临床重点学科艾滋病研究项目(2007-2009)~~

摘　　要：目的分析女性人类免疫缺陷病毒(HIV)感染相关脂肪营养不良(LD)综合征患者体成分变化特点。方法选取2002年1月至2009年12月在我院接受高效抗逆转录病毒治疗的成年女性HIV感染患者25例,根据临床是否出现脂肪营养障碍将患者分为LD组与非LD组。12例健康体检者为对照组。行双能X线骨密度测量仪测量并分析LD组、非LD组及对照组体成分的变化。结果 25例HIV感染患者的全身脂肪量与高效抗逆转录病毒治疗时间呈负相关(r=-0.431,P=0.029)。脂肪量与体重和肌量有线性回归关系,其中与肌量呈负相关(r=-0.973,P=0.000)。除上肢外,LD组全身和局部脂肪量均显著低于对照组(P<0.05)。除上肢外,全身和局部骨矿量在LD组和对照组间差异具有统计学意义(P<0.05),且腰椎骨密度在两组间差异具有统计学意义(P=0.001)。LD组肌量较非LD组相对增多,但差异无统计学意义(P>0.05)。结论 HIV-LD患者周围性和中央性脂肪量及骨矿量均减少;与非HIV-LD患者相比,LD患者周围性和中央性肌量相对增多。Objective To study the changes of body composition in females patients with human immunodeficiency virus（HIV）-related lipodystrophy（LD） syndrome（HIV-LD）.Methods Totally 25 female patients who were treated in our hospital from January 2002 to December 2009 were divided into LD group and non-LD group based on the existence of LD.All these patients were receiving highly active antiretroviral therapy（HAART）.In addition,12 healthy women were set as the controls.Total and regional body composition were measured by dual X-ray absorptiometry in all three groups.Results The fat mass（FM） was correlated negatively with the duration of HAART（r=-0.431,P=0.029）.Multiple linear regression analysis showed that FM had positive correlation with weight and negative correlation with lean mass（LM）（r=-0.973,P=0.000）.Total,trunk and leg FM were significantly lower in LD patients than that in controls（P0.05）.Meanwhile,total,trunk and leg bone mineral contents were statistically lower in LD patients than that in controls（P0.05）.Lumbar bone mineral density of LD patients was lower than that of non-LD patients and controls,and there was significant difference between LD patients and controls（P=0.001）.LM of LD patients was higher than that of non-LD patients but without statistical difference（P0.05）.Conclusions The peripheral and central FM and bone mineral contents remarkably decrease in female patients with HIV-LD.However,HIV-LD patients tend to have higher LM than non-LD patients.

关 键 词：人类免疫缺陷病毒 脂肪营养不良 脂肪量 骨矿量 肌量 骨密度 

分 类 号：R512.91[医药卫生—内科学]