妊娠中期因子和CD105在人舌鳞状细胞癌中的表达和意义的研究  

Expression of midkine and CD105 in human tongue squamous cell carcinoma and its clinical significance

作　　者：侯德强[1] 陈东[2] 焦晓辉[2] 刘睿[1] 白莉学[1] 王雪艳[1] 

机构地区：[1]齐齐哈尔市第一医院口腔修复科,齐齐哈尔市161005 [2]哈尔滨医科大学附属口腔医学院口腔颌面外科,哈尔滨市150001

出　　处：《口腔医学》2011年第8期459-462,共4页Stomatology

基　　金：黑龙江省卫生厅科研项目(2007-266)

摘　　要：目的观察妊娠中期因子(MK)在舌鳞状细胞癌(简称舌鳞癌)中表达与临床病理因素的关系,以及其与CD105标记的微血管密度(MVD)的相关性。方法采用免疫组化的方法检测57例手术切除的舌鳞癌组织中MK和CD105标记的微血管密度情况,并对其与舌鳞癌临床病理特征的关系进行统计学分析。结果 MK在舌鳞癌组织中有表达,其中舌鳞癌细胞的细胞质及细胞膜均见表达。MK的表达与淋巴结转移存在相关性(P<0.05),而与患者的性别、年龄无关(P>0.05);随着肿瘤临床分期不同MK和MVD的表达不同;MK的表达与MVD呈正相关(P<0.05)。在MK表达阳性组织的MVD均值高于MK表达阴性对照组(P<0.05)。结论 MK在舌癌组织中过表达,且与血管生成具有相关性,两者可联合作为一组有价值的肿瘤标记和预后指标。Objective To evaluate the clinical significance of midkine（MK）,including its relationship between its immunohistochemical expression and clinicopathologic factors,and its correlation with microvessed density（MVD） marked with CD105 antibody in tongue squamous cell carcinoma.Methods Immunohistochemical expression of MK and CD105 was evaluated in tongue squamous cell carcinoma specimens from 57 patients who underwent surgical resection,and the relationship of MK and MVD expression with clinicopathological characteristics was statistically analyzed.Results The expression of MK in tongue squamous cell carcinoma was detected in both cytoplasm and cellular membrane of the tumor cell.The expression of MK and CD105 was significantly correlated with the lymph node metastasis（P0.05）,but not correlated with gender,age（P0.05）.In different clinical stages,the expression of MK and MVD was different.MVD was expressed significantly higher in tumor tissue with positive MK than in that with negative MK（P0.05）.Conclusions Midkine is overexpressed and correlated with angiogenesis in tongue squamous cell carcinoma.A combinative detection of MK and CD105 can be as valuable tumor marker and prognostic factor for tongue squamous cell carcinoma.

关 键 词：中期因子 微血管 舌鳞状细胞癌 预后 

分 类 号：R739.86[医药卫生—肿瘤]