Expression of interleukin-2 in Candidal balanoposthitis and its clinical significance  

作　　者：CHEN Jun ZHOU Yun-xiao JIN Xiao-dong CHEN Shan-wen 

机构地区：[1]Department of Urology First Affiliated Hospital,Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China [2]Department of Gynecology First Affiliated Hospital,Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China

出　　处：《Chinese Medical Journal》2011年第17期2776-2778,共3页中华医学杂志（英文版）

摘　　要：Background Candidal balanoposthJtis （CB） is a common male genital infection. Autoimmune mechanisms may play an important role in the pathOgenesis of CB. Interleukin-2 （IL-2） is an important molecule in cell-mediated immunity. Methods One hundred and one patients were diagnosed with CB using mycology culture in the dermatology and urology clinics in our hospital. Ninety-four healthy males were randomly selected as controls. We studied serum levels of IL-2 of patients with CB using ELISA and analyzed the correlations between serum IL-2 and clinical data. Results Serum IL-2 concentrations in CB patients were significantly lower than that in the control group （（7.80±4.78） vs. （15.44±7.90） rig/L; t=2.27, P 〈0.05）. The incidence of CB in the low-level group was significantly higher than that in the high-level group （70% （71/101） vs. 36% （30/84）, P 〈0.05）. Low levels of serum IL-2, comorbidity with other sexually transmitted diseases （STDs）, and sexual partners with vulvovaginal candidiasis （VVC） increased the risk of CB. Conclusion The pathogenesis of CB is a complex procedure that includes internal autoimmune factors.Background Candidal balanoposthJtis （CB） is a common male genital infection. Autoimmune mechanisms may play an important role in the pathOgenesis of CB. Interleukin-2 （IL-2） is an important molecule in cell-mediated immunity. Methods One hundred and one patients were diagnosed with CB using mycology culture in the dermatology and urology clinics in our hospital. Ninety-four healthy males were randomly selected as controls. We studied serum levels of IL-2 of patients with CB using ELISA and analyzed the correlations between serum IL-2 and clinical data. Results Serum IL-2 concentrations in CB patients were significantly lower than that in the control group （（7.80±4.78） vs. （15.44±7.90） rig/L; t=2.27, P 〈0.05）. The incidence of CB in the low-level group was significantly higher than that in the high-level group （70% （71/101） vs. 36% （30/84）, P 〈0.05）. Low levels of serum IL-2, comorbidity with other sexually transmitted diseases （STDs）, and sexual partners with vulvovaginal candidiasis （VVC） increased the risk of CB. Conclusion The pathogenesis of CB is a complex procedure that includes internal autoimmune factors.

关 键 词：INTERLEUKIN-2 Candidal balanoposthitis 

分 类 号：X[环境科学与工程]