质子磁共振波谱在帕金森病患者纹状体中的应用研究  

Study on Changes of Proton Magnetic Resonance Spectroscopy(1H-MRS) in Corpus Striatum of Patients with Parkinson's Disease

作　　者：邱喜雄[1] 刘品霓[1] 刘立红[1] 蔡晓东[1] 杜立新[1] 雷益[1] 王佩萍[2] 

机构地区：[1]深圳市第二人民医院放射科,广东深圳518035 [2]中山大学附属第五医院预防保健科,广东珠海519100

出　　处：《深圳中西医结合杂志》2011年第4期204-207,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：深圳市科技计划项目(200103099)

摘　　要：目的:利用质子磁共振波谱(1H-MRS)技术研究帕金森病(PD)患者纹状体的代谢变化,评价H-MRS1用于PD的病理生理研究和诊断的价值。方法:采用H-MRS检测15例PD与12例年龄匹配的健康对照者双侧纹状体1N-乙酰天门冬氨酸(NAA)、胆碱复合物(Cho)及肌酸复合物(Cr)含量,比较NAA/Cr、Cho/Cr、NAA/Cho比值。结果:PD组NAA/Cr、Cho/Cr、NAA/Cho分别为(1.2±0.15)、(0.9±0.13)、(1.1±0.14),对照组分别为(1.8±0.12)、(0.9±0.15)、(1.4±0.13)。PD组NAA/Cr、NAA/Cho值减低,与对照组比较差异有统计学意义(P<0.05)。结论:NAA/Cr、NAA/Cho值降低是评估PD患者神经元功能损害的重要指标。1H-MRS对PD患者双侧纹状体进行检测,可以为PD患者的病理生理改变和诊断提供重要信息。Objective To study the metabolism of corpus striatum in patients with Parkinson disease（PD） by proton magnetic resonance spectroscopy（1H-MRS）,and evaluate the clinical value of the technique in the pathophysiological process and the diagnose of PD.Methods The contents of N-acetylaspartate（NAA）,choline compound（Cho） and creatine compound（Cr） in corpus striatum of 15 PD patients and 12 age-matched healthy controls were examined with proton MRS and the ratios of NAA/Cr,Cho/Cr and NAA/Cho were calculated.Results The ratios of NAA/Cr,Cho/cr and NAA/Cho in the PD patients were（1.2±0.15）,（0.9±0.13）,（1.1±0.14） respectively,and those of the healthy controls were（1.8±0.12）,（0.9±0.15）,（1.4±0.13）.The ratios of NAA/Cr,NAA/Cho in PD patients showed significant reduction compared with the controls（P 〈 0.05）.Conclusion The reduction of NAA/Cr and NAA/Cho ratio in PD patients may indicate the dysfunction of the neurons.Proton MRS may provide an important information to understand the pathophysiological process of PD and to diagnose PD by detection bilateral Corpus Striatum

关 键 词：帕金森病 纹状体 磁共振波谱学 

分 类 号：R742.5[医药卫生—神经病学与精神病学]