高度近视眼视网膜电图明视负向反应的研究  

Photopic Negative Response of the Flash Electroretinogram in High Myopia

作　　者：马力[1] 

机构地区：[1]温州医学院附属慈溪医院,浙江省慈溪市315300

出　　处：《中国全科医学》2011年第26期3001-3002,共2页Chinese General Practice

基　　金：浙江省医药卫生科学研究基金(2007A176)

摘　　要：目的探讨不同程度高度近视眼视网膜电图明视负向反应(PhNR)的改变。方法高度近视眼患者20例(40眼)分为高度近视1组(-6.00^-10.00 DS)10例(20眼)和高度近视2组(-10.25^-20.00 DS)10例(20眼),同时选取正常成人10人(20眼)为对照组,应用重庆康华AVE8000视觉电生理仪检查PhNR。结果对照组受试者在强度1(2.000e-1 cd.s/m2)刺激下振幅较强度2(2.000e-2 cd.s/m2)和强度3(2.000e-3 cd.s/m2)明显升高,差异有统计学意义(P<0.05);三种刺激光强度下潜伏期比较,差异无统计学意义(P>0.05)。采用最佳刺激强度(2.000e-1 cd.s/m2)对高度近视1组和2组患者进行PhNR测试,高度近视1组与正常组振幅比较,差异无统计学意义(P>0.05);高度近视1组和对照组振幅较高度近视2组均明显升高,差异有统计学意义(P<0.05);3组间潜伏期比较,差异无统计学意义(P>0.05)。结论随着高度近视度数增加,其视网膜内层功能也受到损伤,PhNR可以作为高度近视眼内层视网膜功能检测的一个视功能评价指标。Objective To evaluate the changes of PhNR in patients with high myopia （HM） of different diop- ters. Methods Fourty eyes （20 cases） with HM were divided into HM group1 （ -6.00 ~ -10.00 DS） and HM group 2 （ - 10. 25 ~ -20.00 DS） . Twenty eyes （ 10 cases） with normal vision were enrolled as the control group. Photopic negative re- sponses （PhNR） were evaluated using AVE8000 examiner of vision electrophysiology. Results The amplitudes of the control group increased notably in response to stimulus intensity No. 1 （2. 000e - 1 cd ~ s/mz ） compared with intensity No. 2 （ 2. 000e - 2 cd · s/mz ） and intensity No. 3 （ 2. 000e - 3 cd ·s/m2 ） with statistical significance （ P 〈 0. 05 ） . Lateneies of the three stimulus intensity displayed no significant differences （P 〉 0. 05 ） . HM group 1 and HM group 2 were examined with optimized stimulation intensity. No significant difference was noted in amplitudes between HM groupl and the control group （ P 〉 0. 05 ） .The amplitudes of HM group 1 and control group remarkably increased in comparison with HM group 2 with statistical significance （P 〈 0. 05 ） . No significant difference in latency was noted among the three groups （ P 〉 0. 05 ） . Conclusion With the in- crease of diopters in high myopia, functional damage of the inner retina advances as well. PhNR examination provides may serve as a visual function evaluating index for inner retina in high myopia.

关 键 词：近视 视网膜 屈光 眼 

分 类 号：R778.11[医药卫生—眼科]