艾司西酞普兰与西酞普兰治疗首发老年抑郁症的临床研究  

Clinical Study on Efficacy and Safety of Escit-alopram VS Citalopram in the Treatment of First-episode Geriatric Depression

作　　者：贾金鼎[1] 杨建章[1] 余学[1] 程粉[1] 张明松[1] 

机构地区：[1]驻马店市精神病医院,河南驻马店463000

出　　处：《中国民康医学》2011年第17期2112-2113,2116,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:比较艾司西酞普兰与西酞普兰治疗首发老年抑郁症的有效性和安全性。方法:将68例首发老年抑郁症患者随机分为A组(艾司西酞普兰)和B组(西酞普兰),疗程6周。用汉密尔顿抑郁量表(HAMD17)、临床总体印象量表(CGI)与不良反应量表(TESS)在治疗前和治疗后第1、2、4、6周末评定疗效与不良反应。结果:A组第1、4、6周末HAMD17与CGI评分均低于B组,两组有显著性差异(t=2.18,2.77,3.2,P<0.05或P<0.01);两组临床疗效有显著性差异(x2=4.19,P<0.05);两组不良反应差异无统计学意义(x2=0.15,P>0.05)。结论:艾司西肽普兰具有良好的抗抑郁效果,比西酞普兰起效更快、症状缓解更明显、疗效更好,而且安全性高,耐受性好,可作为老年抑郁症的一线用药。Objective：To compare the efficacy and safety of Escit - alopram and Citalopram in the treatment of first - episode geriatric depression. Methods：68 patients with first -episode geriatric depression were randomly divided into group A （Escit-alopram） and group B （Citalopram） for 6 weeks＇treatment. Hamilton Depression rating scale（ HAMD 17） , Clinical Global Impression Scale （CGI） and Treatment Emergent symptom scale （TESS） were used to assess the efficacy and side effects respectively before treat ment and after treatment 1,2-4,6 weekends. Results： The scores of HAMD 17 and CGI in the group A were lower than those in the group B in the end of 1,4,6 week, and there was significant difference between the two groups （ t = 2.18,2.77,3.2, P 〈 0. 05 或 P 〈 0.01 ） ; Clinical efficacy was significant difference between both groups （ x2 = 4.19, P 〈 0.05 ） ; There was no significant difference in adverse reactions between both groups （ x2 = 0.15, P 〉 0.05 ）. Conclusions ： In contrast with Citalopram, Escit - alopram has a better antidepressant effect with faster onset , better efficacy, higher safety and well tolerated, and can not only alleviate the symptoms signifi- cantly but also be used as first - line medicine for treating geriatric depression.

关 键 词：老年抑郁症 艾司西酞普兰 西酞普兰 

分 类 号：R749.41[医药卫生—神经病学与精神病学]