诺和龙联合甘精胰岛素治疗48例精神病合并糖尿病的临床观察  

Clinical observation of Repaglinide combined with insulin glargine in treatment of psychiatric patients with diabetes mellitus

作　　者：陈永康[1,2] 黄俊华[1,2] 陈红梅[1,2] 

机构地区：[1]东风公司茅箭医院 [2]十堰市精神病院,湖北十堰442000

出　　处：《中国民康医学》2011年第17期2144-2146,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨诺和龙联合甘精胰岛素在精神病合并糖尿病患者治疗中的疗效。方法:48例精神病合并糖尿病患者随机分为诺和龙与甘精胰岛素组(治疗组)25例,格列吡嗪联合中效鱼精蛋白锌人胰岛素(NPH)组(对照组)23例。依照空腹血糖(FBG)水平调整胰岛素用量,治疗目标值FBG<7.0 mmoL/L,治疗时间12周。观察两组患者治疗前后空腹(FBG)及餐后2 h血糖(2 h PBG)水平、低血糖、糖化血红蛋白(HbAlc)及体质量指数(BMI)等指标的变化情况。结果:两组治疗后FBG、2 h PBG及HbAlc均明显低于治疗前,观察组低血糖发生率明显低于对照组(P<0.05),两组间治疗后血糖无明显差异(P>0.05)。结论:诺和龙与甘精胰岛素可迅速、有效地控制精神病合并糖尿病患者的血糖,低血糖发生率低,具有安全、方便的特点,是精神病合并糖尿病患者控制血糖理想的治疗方案。Objective ：To investigate the therapeutic efficacy of Repaglinide combined with insulin glargine in treatment of psychiatric patients with diabetes mellitus. Methods ：48 cases of psychiatric patients with diabetes mellitus were randomly divided into two groups ： treatment group of Repaglinide combined with insulin glargine （ group A, n = 25） and treatment group of Glipizide combined with Neutral Protamine Hagedom （NPH） Insulin （group B, n = 23 ）. The insulin dosages of these two groups are adjusted according to the fasting blood glucose （FBG） levels. The treatment goal is to keep the FBG levels under 7.0mmol / L, after a 12 - week treatment, the changes of both fasting and postprandial 2h blood glucose （2h PBG） , incidence of hypoglycaemia, glycosylated hemoglobin （HbAle） and body mass index （BMI） of these patients were examined. Results： After a 12 -week treatment, the FBG, 2h PBG, and HbAle in both groups were significantly lower than before, the incidence of hypoglycemia in group A were significantly lower than group B （ P 〈 0.05 ）. Furthermore, the blood sugar of these two groups has no significant differences （ P 〉 0.05 ）. Conclusions： Repagiinide combined with insulin glargine can be quickly and effectively to control blood sugar in psychiatric patients with diabetes mellitus. Also, this therapeutic regimen is safe and convenient as well as keeping lower incidences of hypoglycemia. Therefore, it is an ideal therapeutic regimen for controlling blood glucose in psychiatric patients with diabetes mellitus.

关 键 词：精神病 糖尿病 甘精胰岛素 诺和龙(瑞格列奈) 

分 类 号：R749[医药卫生—神经病学与精神病学] R587.1[医药卫生—临床医学]