新型磺酰胺手性配体的合成与表征  

Synthesis and characterization of novel sulfonamide chiral ligands

作　　者：宗华[1,2] 黄华银[1,2] 边广岭[2] 宋玲[2] 冷一欣[1] 

机构地区：[1]常州大学化学化工学院,江苏常州213164 [2]中国科学院福建物质结构研究所,福建福州350002

出　　处：《化学试剂》2011年第9期773-776,共4页Chemical Reagents

基　　金：福建省自然科学基金资助项目(2010J01055)

摘　　要：以天然L-缬氨酸为手性源,通过保护氨基、缩合、去保护、还原、酰化等简单步骤合成了3种新型的磺酰胺类手性配体。该类反应具有后处理简单、反应温和、产率高等优点。并利用1HNMR、13CNMR、ESI/MS对合成的目标产物进行了表征及结构确认,并初步探索了该类型配体在催化二乙基锌对醛的不对称加成反应中的应用。Three novel sulfonamide chiral ligands were synthesized from natural L-valine through functional group protection,condensation,deprotection,reduction and acylation.The method has such advantages as simple operation,mild reaction conditions and high product yield.The structures were confirmed by 1HNMR,13CNMR and ESI/MS.Some initial work has been done for enantioselective of diethylzinc addition to benzaldehyde using these chiral ligands.

关 键 词：磺酰胺 手性配体 合成 

分 类 号：O621.3[理学—有机化学]