PTEN基因与皮肤肿瘤  

PTEN gene and skin cancer

作　　者：郭泽[1] 周炳荣[1] 李巍[1] 骆丹[1] 

机构地区：[1]南京医科大学第一附属医院皮肤性病科,210029

出　　处：《国际皮肤性病学杂志》2011年第5期320-322,共3页International Journal of Dermatology and Venereology

摘　　要：皮肤肿瘤是一类最常见的肿瘤，在引起皮肤肿瘤发生的诸多原因中，紫外线照射是主要影响因素之一。PTEN是近年来研究较多的一个肿瘤抑制基因，位于染色体10q23，3。目前研究证实，PTEN在多种皮肤肿瘤，如基底细胞癌、鳞状细胞癌、恶性黑素瘤中都起着抑制基因的作用，发现在皮肤肿瘤形成过程中，紫外线照射可引起PTEN失活，对肿瘤的形成可能起着促进的作用。Skin cancer is one of the most common cancers. Ultraviolet irradiation is the predominant environmental factor causing skin cancer. Phosphatase and tensin homolog deleted on chromosome 10 （PTEN） is a tumor suppressor gene located on chromosome 10 q23,3, which has been frequently studied in recent years. There is evidence that PTEN acts as a tumor suppressor in many skin cancers, such as basal cell carcinoma, squamous cell carcinoma, and melanoma. Ultraviolet irradiation can result in the inactivation of PTEN and in turn promote the development of cancer.

关 键 词：皮肤肿瘤 基因 PTEN 紫外线 

分 类 号：R739.5[医药卫生—肿瘤]