香烟烟雾引起的氧化应激在肺泡Ⅱ型上皮细胞损伤中的作用  

The Role of Oxidative Stress Induced by Cigarette Smoke in Type Ⅱ Alveolar Epithelial Cells

作　　者：张强弩[1] 焦宗宪[1] 

机构地区：[1]兰州大学基础医学院病理学研究所,兰州730000

出　　处：《医学综述》2011年第17期2568-2571,共4页Medical Recapitulate

基　　金：兰州大学中央高校基本科研业务费专项资金(lzujbky-2009-92);教育部留学回国人员科研启动基金~~

摘　　要：香烟烟雾中含有自由基等大量的强氧化剂,因而可以导致氧化应激。氧化应激可对肺泡Ⅱ型上皮细胞(AECⅡ)造成损伤,但是其对AECⅡ造成损伤的机制至今还未完全清楚,近期这个领域研究的热点集中在三个方面:氧化应激诱导的AECⅡ凋亡、氧化应激与炎性反应的相互作用对AECⅡ的损伤以及氧化应激对AECⅡ结构和功能的直接损伤。AECⅡ损伤与肺部损伤有密切关系,对其损伤机制的研究,有助于呼吸道疾病的诊断和治疗。Smoking is a risk factor which can induce and aggravate respiratory diseases. Cigarette smoke contains abundant oxidants such as free radicals. Oxidative stress caused by cigarette smoke results in the destruction of the type Ⅱ alveolar epithelial cell（ AEC Ⅱ ）. However,the mechanisms of the destruction of AEC Ⅱ caused by oxidative stress are still unclear. Recent studies are focused on apoptosis, inflammation and damage of cell structures and functions. The destruction of AEC Ⅱ associates closely with lung injury, so the studies of how oxdative stress works in the destruction process of AEC Ⅱ will contribute to respiratory diseases diagnosis and therapy.

关 键 词：香烟烟雾 氧化应激 肺泡Ⅱ型上皮细胞 凋亡 炎性反应 

分 类 号：R365[医药卫生—病理学]