DNA甲基化与结直肠癌  

DNA Methylation in Colorectal Cancer

作　　者：文玉[1] 李晓燕[1] 

机构地区：[1]昆明医学院第一附属医院消化内科,昆明650032

出　　处：《医学综述》2011年第17期2602-2604,共3页Medical Recapitulate

摘　　要：DNA甲基化是肿瘤常见的表观遗传学改变,是一种在原核和真核生物基因组中常见的复制后修饰,参与体内多种重要的生理过程,同时在肿瘤的发生和发展中也起着重要的作用。近年来,DNA甲基化成为表观遗传学研究的热点,一些甲基化事件可望成为早期诊断结直肠癌的重要分子靶标,因此对结直肠癌DNA甲基化进行深入研究,对于结直肠癌的临床早期诊断、治疗和预防都具有重要的指导意义。现就结直肠癌中的DNA甲基化研究进展作简要综述。DNA methylation has been recognized as a common epigenetic change in human cancers, which is a postreplicative modification occurring in most prokaryotic and eukaryotic genomes,with a variety of important biological functions and an important role in the genesis and development of tumors. Recently, DNA methylation has become one of epigenetics research hot topics. Several methylation events could be important therapeutical targets. Deep study of DNA methylation is of great significance to the early diagnosis,treatment and precaution of colorectal cancer. Here is to summarize the research progress of DNA methylation in colorectal cancer.

关 键 词：表观遗传学 DNA甲基化 结直肠癌 

分 类 号：R735.35[医药卫生—肿瘤] R735.37[医药卫生—临床医学]