胃腺癌中HPSE、VEGF的表达与临床病理特征的关系  

Relationship between the expression of HPSE、VEGF with clinical pathological characteristics in gastric carcinoma

作　　者：陈锦章[1] 谢剑明[1] 李爱民[1] 郑航[1] 罗荣城[1] 

机构地区：[1]南方医科大学南方医院肿瘤科,广州510515

出　　处：《重庆医学》2011年第26期2629-2630,2632,I0003,共4页Chongqing medicine

摘　　要：目的探讨胃腺癌组织中乙酰肝素酶(HPSE)、血管内皮生长因子(VEGF)蛋白的表达与临床病理特征及生存期的关系。方法选择2000年1月至2004年1月在本院手术切除并经病理确诊为胃腺癌的患者103例,应用免疫组织化学方法检测103例胃腺癌标本中HPSE、VEGF蛋白的表达,并将检测结果与临床病理特征进行综合分析。结果 HPSE、VEGF蛋白的阳性表达率分别为57.3%(59/103)、46.6%(48/103),表达阳性与阴性患者生存时间差异有统计学意义(P<0.05);胃腺癌中HPSE、VEGF蛋白表达呈正相关(r=0.675,P<0.05)。结论 HPSE、VEGF的表达可作为临床判定胃癌恶性程度及评估预后的指标,对指导靶向治疗和预测预后具有一定的意义。Objective To investigate the expression of heparanase （HPSE） ,vascular endothelial growth factor（VEGF）in gastric cancer and their relationships with clinical pathologic characters and survival. Methods The expression of HPSE,VEGF in gastric cancer were studied by immunohistochemical technique with their relation to follow up data, analyzed their detect outcome with clinical pathologic characters. Results HPSE and VEGF proteins were detected in 57. 3 % （59/103） and 46.6 % （48/103） amongst the 103 tissue samples of gastric adenoma patients, respectively. Both proteins were undetectable using this method in the 20 healthy control samples. There is no significant correlation between HPSE, VEGF protein expression and the patientsr gender, age, size and site of the tumor and the degree of differentiation（P〉0.05）. HPSE and VEGF protein expressions correlate with tumor＇s infiltration depth,lymph node metastasis,distal metastasis and pathological stages（P〈0.05）. The median survival time for patients with HPSE or VEGF protein expression is 12.0 months and 11.0 months respectively. The difference is statistically significant（P〈0. 05）compared to HPSE or VEGF negative patients whose median survival time is 70. 0 months. The expressions of HPSE and VEGF proteins are positively correlated in gastric cancers（r =0. 675,P〈0.05）. Conclusion The results suggest that the high expression of HPSE, VEGF is an useful tool for providing information about the malignant degree, prognosis, and may be as a gaiding in targeted therapy selection for patients with gastric carcinoma.

关 键 词：胃肿瘤 血管内皮生长因子A 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]