虾青素对活性氧所致细胞膜损伤的保护作用研究  

Protective Effect of Astaxanthin on Membrane Damage Induced by Reactive Oxygen Species

作　　者：曹秀明[1,2] 杨菲菲[1,2] 徐德林[1,2] 

机构地区：[1]国家教育部抗肿瘤天然药物工程研究中心 [2]哈尔滨商业大学生命科学与环境科学研究中心,黑龙江哈尔滨150076

出　　处：《食品与药品》2011年第9期319-322,共4页Food and Drug

摘　　要：目的研究虾青素保护活性氧(ROS)所致细胞膜损伤的作用。方法用ROS建立细胞膜损伤模型,测定细胞膜谷胱甘肽(GSH)含量;细胞膜ATP酶活性;亚硝酸盐法测定细胞膜一氧化氮(NO)含量;细胞内ROS含量变化。结果虾青素可有效地提高损伤细胞膜的GSH含量、恢复ATP酶活性并降低NO和ROS含量。结论虾青素有保护ROS所致细胞膜损伤的作用,其机制与抗氧化作用有关。Objective To study the protective effect of astaxanthin on membrane damage induced by reactive oxygen species （ROS）. Methods The damage model of cell membrane was made by ROS. The protective effect of astaxanthin on the oxidative damage of cell membrane was evaluated by the determinations of the contents of cell membrane GSH, NO, ROS, and the activity of ATPase. Results The astaxanthin enhanced the content of damaged cell membrane GSH, restored the activity of ATPase effectively, and reduced the contents of NO and ROS. Conclusion Astaxanthin is beneficial in protecting membrane system from oxidative damage induced by ROS, and its mechanism is related to anti-oxidation.

关 键 词：虾青素 活性氧 细胞膜损伤 抗氧化剂 

分 类 号：Q241[生物学—细胞生物学]