帕罗西汀联合银杏叶片治疗血管性抑郁的疗效研究  

The efficacy of combined treatment with folium ginko preparation and paroxetine in vascular depression

作　　者：罗向东[1] 吴景芬[1] 周波[1] 肖军[1] 

机构地区：[1]四川省医学科学院.四川省人民医院神经内科,四川成都610072

出　　处：《西部医学》2011年第9期1644-1646,共3页Medical Journal of West China

基　　金：四川省卫生厅科研课题(编号:080367)

摘　　要：目的探讨帕罗西汀联合银杏叶片治疗血管性抑郁的疗效与安全性。方法 90例血管性抑郁患者随机分为帕罗西汀联合银杏叶片治疗组47例和单用帕罗西汀对照组43例,疗程均为8周。在治疗前和治疗后4周、6周、8周采用汉密尔顿抑郁量表(HAMD)评价临床疗效并记录不良反应。结果治疗8周后,帕罗西汀合并银杏叶片治疗组有效率为68.08%,帕罗西汀对照组有效率为51.16%,两组比较,疗效及HAMD总分的差异均具有统计学意义(P<0.01)。帕罗西汀合并银杏叶片治疗组不良反应发生率为44.68%,帕罗西汀治疗组为41.86%,差异没有统计学意义(P>0.05)。结论帕罗西汀合并银杏叶片治疗血管性抑郁的疗效优于单用帕罗西汀,且安全性好。Objective To investigate the efficacy of combined treatment with folium ginko preparation and paroxetine in vascular depression.Methods Patients with vascular depression（n=90） were randomly divided into Folium Ginkgo preparation combined with Paroxetine group（combined therapy group,n=47） and single paroxetine group（control group,n=43）.Before treatment and 4,6 and 8 weeks after treatment,the clinical efficacy and adverse effect were measured by the Hamilton depression scale（HAMD）.Results After 8 weeks treatment,the effective rate of the Folium Ginkgo preparation combined with Paroxetine group was 68.08%,and the single paroxetine group＇s effective rate was 51.16%.There was statistical difference in the two groups（P〈0.01）.In addition,the HAMD scores of combined therapy group was remarkably lower than the control group（P〈0.01）.The incidence of adverse effect in combined therapy group was 44.68%,and the control group was 41.86%.There was no statistical difference in the two groups（P〈0.05）.Conclusion The efficacy of combined treatment of folium ginkgo preparation and paroxetine in vascular depression is better and safer than single paroxetine.

关 键 词：血管性抑郁 帕罗西汀 银杏叶提取物 

分 类 号：R749.1[医药卫生—神经病学与精神病学]