Nogo基因和雌激素受体基因多态性与多发性硬化发病易感性的关系  

The relationship between the gene polymorphism of Nogo and estrogen receptor gene to multiple sclerosis

作　　者：李晟[1] 刘伟[1] 杨昆胜[2] 方瑾[1] 肖建新[1] 叶荣苹[1] 黄智慧[1] 

机构地区：[1]中国人民解放军第一一八医院内科,浙江温州325000 [2]昆明医学院附属第一医院神经内科,云南昆明650032

出　　处：《中风与神经疾病杂志》2011年第8期688-691,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的分析Nogo基因和雌激素受体基因单核苷酸多态性与多发性硬化(Multiple sclerosis,MS)遗传易感的相关性。方法以60例临床及实验室确诊的MS患者和120例与入组患者种族、年龄、性别相匹配健康志愿者为研究对象,利用聚合酶链(PCR)电泳分析Nogo基因多态性,并用聚合酶链限制性长度多态性分析(PCR-RFLP)技术检测雌激素受体基因多态性。结果多发性硬化患者PvuⅡ基因和Nogo基因多态性分布与对照组相比具有显著差异。结论 PvuⅡ基因和Nogo基因多态性可能是多发性硬化发生的一个遗传学危险因素。Objective To investigate the relationship between the gene polymorphism of Nogo and estrogen receptor gene to multiple sclerosis（MS）.Methods A total of 60 MS patients with a clinical or laboratory definition MS according to the McDonald criteria were studied.Another 120 controls were randomly selected from hospital staff of non-autoimmune diseases and healthy individuals.Estrogen receptor genotypes were determined by PCR digested by specific restriction enzymes and Nogo genotypes were determined by PCR.Results There was significant difference in genotype and allele distribution of Nogo and PvuⅡ polymorphism between the MS patients and the controls（P〈0.05）.Conclusion The polymorphism of Nogo gene and PvuⅡ gene are associated with multiple sclerosis in Chinese population.

关 键 词：NOGO基因 雌激素受体基因 多发性硬化 聚合酶链式反应 

分 类 号：R744.51[医药卫生—神经病学与精神病学]