度洛西汀与舍曲林治疗老年期抑郁症的对照研究  

A comparative study of Duloxetine versus Hydrochloride in the treatment of late-onset patients with depression

作　　者：李宝珠[1] 李洪英[1] 

机构地区：[1]天津市安定医院,天津300222

出　　处：《中外医学研究》2011年第27期9-11,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的观察度洛西汀与舍曲林治疗老年抑郁症的临床疗效及安全性。方法将76例符合ICD-10抑郁症诊断标准的老年抑郁症患者随机分为两组,应用度洛西汀和舍曲林各38例进行随机对照研究,治疗时间为8周。疗效采用汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)进行评定,不良反应采用副反应量表(TESS)进行评定。结果完成8周治疗后,两组间总体疗效比较差异无统计学意义,HAMD和HAMA总分治疗前后比较差异有统计学意义(P<0.05),两组间比较差异无统计学意义,但焦虑/躯体化、睡眠障碍等因子分比较,两组间差异有统计学意义,两组间不良反应比较差异无统计学意义,但度洛西汀起效快。结论度洛西汀治疗老年期抑郁症疗效好,安全性高,临床上特别适用于伴有躯体化症状的抑郁症老年患者。Objective To evaluate the efficacy and safety of duloxetine in the treatment for late - onset patients with depression. Methods Seventy - six late - onset patients with depression were randomly divided into study group （ receiving duloxetine） and control group （ receiving Hydrochloride）. Efficacy and side effects were assessed with HAMD. HAMA and TESS respectively before and after treatment. Results After eight weeks, the efficacy showed no differences between two groups. No significant difference Was found in all scores of HAMD and HAMA between the two groups. But the scores of anxiety/somatization and sleep disorder in study group were significantly different from control group. No difference Was found in the adverse event between the two groups. Conclusion Duloxetine shows better efficacy and high safety in thetreatment of late - onset depression, which could be recommended to all late - onset patients with somatization symptoms.

关 键 词：度洛西汀 舍曲林 老年抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]