他汀药物在低密度脂蛋白胆固醇偏低的动脉粥样硬化性脑梗死患者中二级预防的研究  

作　　者：何柳[1] 张仲[1] 高励[1] 郝玉曼[1] 刘艳[1] 王蕾[1] 赵晓玲[1] 周弋人[1] 张海涛[1] 刘智磊[1] 

机构地区：[1]成都市第三人民医院神经内科,四川成都610031

出　　处：《医学信息（中旬刊）》2011年第9期4643-4644,共2页Medical Information Operations Sciences Fascicule

摘　　要：目的:探讨他汀治疗在低密度脂蛋白胆固醇(LDL-c)偏低的动脉粥样硬化性脑梗死(ACI)患者中二级预防的疗效。方法:入选103例LDL-c小于2.1mmol/L的ACI患者,随机分为常规治疗组(51例)和他汀治疗组(52例),分析比较组间和组内阿托伐他汀治疗1月后LDL-c水平的变化,同时观察患者急性期(1月)内和1年随访期间脑血管事件及神经功能缺损情况。结果:治疗1月后,他汀治疗组的LDL-c水平和治疗前比较下降无显著性差异(P>0.05),但与常规治疗组相比,急性期内患者神经功能缺损评分降低,差异有统计学意义(P<0.05)。随访1年期间缺血性脑卒中的复发率较常规对照组降低,神经功能缺损的加重也显著低于常规治疗组(P<0.05)。结论:LDL-c偏低的ACI患者因早期启动他汀治疗而受益,其原因可能并不是单一依赖降脂这一途径,而是通过其他神经保护功能起到作用。Objective：To evlaute statin therapy for secondary prevention of atherosclerotic cerebral infarction （ACI） pataints with low low-density lipoprotein-cholesterol （LDL-c） level.Methods：03 ACI pataints with low LDL-c level were randomly divided into conventional treatment group（n=51） and statin treatment group （n=52） with added atorvastatin 20 mg per day.he level of LDL-c were measured before and after one month treatment,Simultaneously stroke events and the nerve function damage situation of both groups were observed in the acute stage and 1 year revisit period.Results：he LDL-c level of statin treatment group was no significantly diference before and after one month treatment （P0.05）,but nerve function damage grading of statin treatment group was significantly lower than conventional treatment group （P0.05） in both the acute stage and 1 year revisit period.Also the stroke recurrence rate of statin treatment group was significantly lower than conventional treatment group（P0.05）.Conclusion：ACI pataints with low LDL-c level obtain benefits because of the early start statin treatment.

关 键 词：动脉粥样硬化性脑梗死 他汀治疗 二级预防 低密度脂蛋白胆固醇 

分 类 号：R743.33[医药卫生—神经病学与精神病学]