405例非霍奇金淋巴瘤患者乙型肝炎病毒感染率分析  

An analysis of hepatitis B virus infection rate in 405 cases of non-Hodgkin lymphoma

作　　者：刘卫平[1] 郑文[1] 王小沛[1] 宋玉琴[1] 谢彦[1] 涂梅峰[1] 林宁晶[1] 平凌燕 应志涛[1] 邓丽娟[1] 张晨[1] 朱军[1] 

机构地区：[1]北京大学临床肿瘤学院、北京肿瘤医院暨北京市肿瘤防治研究所淋巴肿瘤内科、恶性肿瘤发病机制及转化研究教育部重点实验室,100142

出　　处：《中华血液学杂志》2011年第8期521-524,共4页Chinese Journal of Hematology

摘　　要：目的研究非霍奇金淋巴瘤（NHL）患者中乙型肝炎病毒（HBV）感染率。方法采用ELISA法检测NHL患者血清中HBV血清学标志物，并与全国普通人群HBV检出率对比。结果405例NHL患者的HBsAg阳性率、抗-HBs阳性率、抗-HBc阳性率分别为11．6％、39．8％和47．9％，与全国普通人群比较，差异均有统计学意义（P值均〈0．01）。B细胞NHL和T细胞NHL的HBsAg阳性率、抗-HBs阳性率、抗-HBc阳性率分别为13．3％对7．1％（P=0．083）、40．6％对37．5％（P=0．567）、53．2％对33．9％（P=0．001）。93例NHL患者中22例（23．7％）HBVDNA阳性，其中38例HBsAg阳性患者中19例（50．0％）HBVDNA阳性，HBsAg阴性但抗-HBc阳性的55例患者中3例（5．5％）HBVDNA阳性。结论NHL患者的HBV感染率高于全国普通人群，其中隐匿性HBV感染是不容忽视的问题。B细胞NHL患者的抗-HBc阳性率高于T细胞NHL患者。NHL患者如果合并HBV感染，则在抗肿瘤治疗前应该给予抗HBV治疗以预防病毒再激活。HBV与NHL的关系值得进一步研究。Objective To analyze the status of hepatitis B virus （HBV） infection in non-Hodgkin lymphoma （NHL） patients. Methods The serum HBV markers in NHL patients were detected by enzymelinked immunosorbent assay（ELISA）. The infection rate of HBV in NHL patients was compared with that in nationwide general population. Results The positive rates of HBsAg, anti-HBs and anti-HBc in 405 cases of NHL were 11.6% , 39.8% and 47.9% , respectively, which were statistically different from those in general population（P 〈0.01 ）. The positive rates of HBsAg, anti-HBs and anti-HBc in B-cell NHL and T-cell NHL were 13.3% vs 7.1% （P=0.083）, 40.6% vs 37.5% （P=0.567） , 53.2% vs 33.9% （P=0.001）, respectively. The HBV DNA positive rate was 23.7% in 93 cases of NHL, and was 50.0% in 38 cases of HBsAg-positive NHL while 5.5% in 55 cases of HBsAg-negative but HBcAb-positive NHL. Conclusions The infection rate of HBV in NHL patients is higher than that in general population, in which occult hepatitis B vires infection can not be ignored. The positive rate of anti-HBc in B-cell NHL is significantly higher than that in T-cell NHL. For NHL patients infected with HBV, prophylactic anti-HBV therapy to prevent viral reactivation should be given before the anti-cancer treatment. Further study in the relationship between HBV and NHL should be carried out in the future.

关 键 词：淋巴瘤 非霍奇金 肝炎病毒 乙型 

分 类 号：R733[医药卫生—肿瘤] R51[医药卫生—临床医学]