HSPA5基因3′UTR区多态性与肝细胞癌的相关性  

Association between the polymorphisms in the 3' UTR of HSPA5 gene and hepatocellular carcinoma

作　　者：申鸿卓[1] 王金龙[1] 潘东晓[1] 罗凯[1] 朱萧[1] 

机构地区：[1]广州医学院附属肿瘤医院肿瘤研究所,广东广州510095

出　　处：《解剖学研究》2011年第4期252-254,共3页Anatomy Research

基　　金：国家自然科学基金(81071697);广州市教育局基金(10A192);广州市卫生局基金(201102A213005)

摘　　要：目的调查70kDa热休克蛋白5(HSPA5)基因3′非翻译区(UTR)的多态性与HCC发病风险之间的关系。方法从576例肝细胞癌患者和539例在性别和年龄上匹配的健康对照者外周血中提取DNA,采用TaqMan检测HSPA5基因3′UTR区的rs16927997、rs1140763和rs12009。结果连锁不平衡的分析确定了3种单倍型和6种双倍型。等位基因、基因型、单体型和双体型在肝癌患者和正常对照组之间的分布没有显著差异。结论本研究表明,HSPA5基因3'UTR的多态性不是有效预测肝细胞癌风险的诊断标志物。Objective To investigated the possible association between the polymorphisms in the 3＇ untranslated region（UTR） of HSPA5 and hepatocellular carcinoma（HCC） risk.Methods DNA from 576 patients with HCC and 539 sex-and age-matched healthy controls was typed for rs16927997,rs1140763 and rs12009 in the HSPA5 gene by TaqMan assays.Results HSPA5 gene has 3 haplotypes and 6 diplotypes in the 3＇ UTR.The distributions of allelotype,genotype,haplotype and diplotype in HCC patients were not significantly different from that in controls.Conclusion The present study suggested that polymorphisms in the 3＇ UTR of HSPA5 were not useful diagnostic markers to predict the HCC risk.

关 键 词：热休克蛋白5 肝细胞癌 多态性 3′非翻译区 

分 类 号：R735.7[医药卫生—肿瘤]