灵芝粗多糖对糖尿病小鼠的降血糖作用  

The Hypoglycemic Effects of Crude Polysaccharides Extract from Ganoderma lucidum in STZ-induced Diabetes Mellitus Mice

作　　者：肖春[1,2,3] 吴清平[2] 蔡玟[4] 谭剑斌[4] 黄俊明[4] 杨小兵[2] 

机构地区：[1]中国科学院南海海洋研究所,广东广州510301 [2]广东省微生物研究所广东省菌种保藏与应用重点实验室,广东广州510070 [3]中国科学院研究生院,北京100049 [4]广东省疾病预防控制中心,广东广州510000

出　　处：《中国食用菌》2011年第5期37-39,共3页Edible Fungi of China

基　　金：广东省科技计划项目(项目编号:2008A020100024、2009GB2E000279)

摘　　要：研究灵芝粗多糖对糖尿病小鼠的降血糖作用。灌胃5周后,剂量组与糖尿病模型对照组的血糖,有显著性差异(p<0.01),高剂量组与低剂量组的血糖水平,组间差异显著(p<0.01);剂量组小鼠的血清胰岛素值与糖尿病模型对照组比较,显著降低。灵芝粗多糖能显著降低糖尿病小鼠的空腹血糖,并呈现一定的剂量依赖关系,但其降血糖机理不是刺激胰岛素的分泌。The hypoglycemic effect of Ganoderma lucidum crude polysaccharides （GLP） in type 2 diabetes mellitus （DM） mice and hypoglycemic mechanism were investigated. The results showed that after five weeks, there existed a significant difference （p〈0.01） in serum glucose between the test groups and the model control group, as well as between the high and the low-dose groups. However, GLP had no obvious effect on serum insulin. GLP was able to significantly decrease fasting blood glucose level in DM mice in certain dose-dependent relationship. However, the hypo- glycemic of GLP was not activated upon stimulation of insulin secretion.

关 键 词：灵芝粗多糖 降血糖活性 糖尿病 

分 类 号：R285[医药卫生—中药学]