基质金属蛋白酶的活性调控与龋病  

Research progress on matrix metalloproteinase activity regulated by high glucose and the relationship with dental caries

作　　者：刘佳[1] 凌均棨[1] 

机构地区：[1]中山大学光华口腔医学院.附属口腔医院牙体牙髓病科,广州510055

出　　处：《国际口腔医学杂志》2011年第5期574-577,共4页International Journal of Stomatology

摘　　要：龋病表现为牙本质无机物脱矿,多种外源性和内源性蛋白质水解酶可分解牙本质有机质。基质金属蛋白酶(MMP)是存在于细胞外基质中最主要的酶系统,可降解牙本质有机质,故在龋病的发生发展过程中发挥着重要的作用。本文就MMP家族,高糖调节基质金属蛋白酶及其活性,高糖调控MMP活性的信号通路,MMP和高糖与龋病的关系等研究进展作一综述。Caries is a process of degradation of dentin matrix by various proteolytic enzymes from bacteria and human host after dentin demineralized.Matrix metalloproteinase（MMP）,as the main endogenous enzymes,play important roles in caries development.The research progresses on MMP activity regulated by high glucose put a new direction for caries development in diabetics.

关 键 词：龋病 基质金属蛋白酶 牙本质 

分 类 号：R781.1[医药卫生—口腔医学]