长春胺缓释胶囊对卒中后抑郁和神经功能恢复的作用观察  

Observation on the effect of vinpocetine sustained-release capsules on post-stroke depression and recovery of neurological function

作　　者：匡良洪[1] 肖胜[1] 肖劲松[2] 

机构地区：[1]黄石市中心医院神经科,湖北省黄石435000 [2]武汉大学中南医院神经科武汉大学985认知-神经信息平台

出　　处：《中国基层医药》2011年第18期2471-2473,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察长春胺缓释胶囊对卒中后抑郁及神经功能恢复的治疗效果。方法将64例急性卒中后抑郁患者随机分为治疗组（34例）和对照组（30例），两组均接受常规药物治疗，治疗组同时加用长春胺缓释胶囊治疗。治疗前、治疗后6周、12周应用Hamilton抑郁量表（HAMD）24项评价抑郁状况，采用简易智能状态量表（MMSE）、美国国立卫生研究院卒中量表（NIHSS）和日常生活活动能力量表（ADL）15项评价患者的认知和神经功能状况。结果治疗后6周、12周时治疗组HAMD、NIHSS和ADL评分较对照组降低（均P〈0．05），MMSE评分较对照组增加（P〈0．05）。治疗组对卒中后抑郁的治愈率和总有效率分别为38％和91％，高于对照组的20％和73％（均P〈0．05）。结论长春胺缓释胶囊治疗卒中后抑郁有效，能改善患者情绪状态及促进神经功能恢复。Objective To observe the effect of vinpocetine sustained-release capsules on post-stroke depres- sion and recovery of neurological function. Methods A total of 64 patients with acute post-stroke depression were randomly divided into Vinpocetine sustained-release capsules group （34 cases） and control group （30 cases）. Conventional therapy was given to both groups. To the treatment group, vinpocetine sustained-release capsules was given at the same time. Depression status was assessed with Hamilton Rating Depression Scale（HAMD）. Meanwhile, Mimi-Mental State Examination（MMSE） ,National Institutes of Health Stroke Scale（NIHSS） and Activities of Daily Living（ADL） were given in to both groups. Results After 6 to 12 weeks＇ therapy,the total score of HAMD,NIHSS and ADL of Vinpocetine group were significantly lower than the control group （ all P 〈 0. 05 ）, MMSE score increased significantly （ P 〈 0.05） in Vinpocetine group. The curative rate and effective rate of Vinpocetine group were 38% and 91%. It was significantly higher than the 20% and 73 % 0f the control group （ all P 〈 0.05 ）. Conclusion Vinpocetine sustained- release capsules was effective to treat post-stroke depression. It could improve the emotional state of patients and promote the recovery of neurological function.

关 键 词：脑血管意外 长春胺 抑郁 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]